Lurker > COVxy

Let's not pretend like admissions or any process like that is ever going to be meritocratic, though.
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DarkRoast posted...

COVxy posted...

DarkRoast posted...

It's not clear if they're referring to in utero use or post-birth exposure.

That doesn't really matter, if they observed effects of gene methylation in children it would indeed be potentially an important finding, either way.

Unfortunately for both of us it seems to be point mutation rate.

This is true, but like I said, no matter what the article actually says, it was a silly thing for you to post. My guess is that you just misread the OP, but you double downed on it.
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DarkRoast posted...

It's not clear if they're referring to in utero use or post-birth exposure.

That doesn't really matter, if they observed effects of gene methylation in children it would indeed be potentially an important finding, either way.
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DarkRoast posted...

Really? You sure know a lot about the article that TC hasn't even shown.

I'm responding to the same information as you, which is:

Fam_Fam posted...

study that found that marijuana use affected the DNA of children of users, and that more use correlated with larger changes in DNA.

Regardless as to what the study ACTUALLY says, your comment was silly.
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DarkRoast posted...

Which is crazy from a biological standpoint since methylation is necessary for a large number of biological processes.

And the impact of this on offspring is hotly debated.

Which is why I said "it's debatable".

Quit arguing in circles just because you're so hot and bothered.

This is about observed effects in children, not parents...
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DarkRoast posted...

COVxy posted...

DarkRoast posted...

COVxy posted...

DarkRoast posted...

If this is related to methylation and not mutation rate, the actual significance is debatable.

This is pretty fucking stupid coming from an MD. I was writing up a response but couldn't even finish.

Cool rebuttal

Asshole attitude not called for

A metric fuckton of biological function is mediated by methylation.

Histone methylation is necessary for the formation of new memories. Synaptic maintenance in general.

Seems incredibly silly, almost ill informed, to wave off methylation effects because they aren't direct mutations lol.

No, it isn't.

As evidenced in my thing called a "source"

Jesus fuck.

The point wasn't regarding inheritance, there's a shit ton of biological pathways where drug use can affect off spring, you know. So the only one running off about necessity of inheritance of epigenetic effects is you.

The OP referenced observed effects in the children, and you stated that if it's just methylation and not mutation, not necessarily something to write home about. Which is crazy from a biological standpoint since methylation is necessary for a large number of biological processes. I only know in depth about brain related ones, by my guess is that any system that depends on the regulation of protein production (which should be just about all of them) is going to heavily depend on methylation.
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DarkRoast posted...

COVxy posted...

DarkRoast posted...

If this is related to methylation and not mutation rate, the actual significance is debatable.

This is pretty fucking stupid coming from an MD. I was writing up a response but couldn't even finish.

Cool rebuttal

Asshole attitude not called for

A metric fuckton of biological function is mediated by methylation.

Histone methylation is necessary for the formation of new memories. Synaptic maintenance in general.

Seems incredibly silly, almost ill informed, to wave off methylation effects because they aren't direct mutations lol.
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Banana_Cyanide posted...

COVxy posted...

CoffeeBeanz is, which is who I was talking too.

I'm in biomedical sciences broadly, but I'm finishing up my PhD in neuroscience.

I just looked up the account and apparently it's closed.

Yeah, she closed it and opened DarkRoast, afaik.
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MrPeppers posted...

The worst are college-educated individuals who know how to google studies and read abstracts, but aren't versed enough in analyzing the literature to actually parse through what's supportive and what's probably not supportive.

I honestly had no clue how to analyze a study until I was forced to through postgraduate training, and I suspect that most people with just undergraduate degrees have no clue what they're doing.

Also, this is absolutely accurate. Unless the undergrad has had extensive training in a lab, which usually they haven't. It takes a couple of years before an undergrad trained in my current lab is reading the papers with any form of critical lens.
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Banana_Cyanide posted...

COVxy posted...

Naw.

I know someone on here is an MD but I can't remember who it is.

CoffeeBeanz is, which is who I was talking too.

I'm in biomedical sciences broadly, but I'm finishing up my PhD in neuroscience.
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Banana_Cyanide posted...

COVxy posted...

This is pretty fucking stupid coming from an MD. I was writing up a response but couldn't even finish.

Wait, you are an MD right?

Naw.
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DarkRoast posted...

If this is related to methylation and not mutation rate, the actual significance is debatable.

This is pretty fucking stupid coming from an MD. I was writing up a response but couldn't even finish.
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The prestige factor at universities is bullshit anyway lol.
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Don't think I've ever seen her more frustrated with the lab before.

*shrugs*
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Vertania posted...

TC is now a confirmed conspiracy theorist

Someone's butthurt that they are the butt of the joke because they believe in pizzagate lol.
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pikachupwnage posted...

ThugLife247 posted...

Isnt this literal slavery

How? Your job pays you and than you get food stamps on top of that.

Fun fact: when I turned 18 I was forced into full time volunteer work to maintain me and my Mom's foodstamps. I was quite literally an indentured servant for a year before I could find a paying job.
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Anyone who supports this has likely never been in a circumstance where food stamps were necessary.
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Up.
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M_Live posted...

This is why Republicans don't believe in science

Though I think this is a bit much. I certainly don't think it's a good look, but the anti-science stance of republicans long predates shenanigans like this, and mostly comes from direct ties to industries whose profits are in peril due to regulation.
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https://nationalpost.com/news/world/editors-investigate-after-science-journal-publishes-study-with-trumps-face-on-monkey-feces

Zoomed in:


I thought it was pretty funny, but thinking about it more carefully, I agree more with this blog:
http://merenlab.org/2018/12/17/face-on-a-turd/

But stepping back, perhaps we can all agree that one of the most important ideals of the scientific endeavor in most simple terms is to set a high bar for evidence-based accumulation of knowledge.

There are few things that can go against this ideal more than celebrating a public figures face on a turd in a peer-reviewed study. If you think this is a well-deserved response to the representative of an anti-science and anti-scientist movement, you have just missed one of the rare opportunities to be better than the biased and damaging ideology you criticize.

It's kinda a bad look.
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I'd say 3%. The chance that rikasa is a woman and not a man pretending to be a woman to hold credit while spouting their opinions about women.
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I think my perception of the coverage when it was happening was that there were risks he took and given that there wasn't anything particularly actionable about the information, it seemed the risk wasn't quite worth it.
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OprahJimfrey posted...

COVxy posted...

It's funny how much they are shoving it in people's faces, that all they care about is making money off their stupid supporters, and yet their supporters don't see it.

Oh please. Like the coddled liberals on YouTube arent doing the same? Fuck off.

I don't think you should be taking political commentary from youtube seriously to begin with lmao.
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It's funny how much they are shoving it in people's faces, that all they care about is making money off their stupid supporters, and yet their supporters don't see it.
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Typically the usage being discussed here is when turbonerds are attempting to defend their sexism with pseudoscience. Actual scientific use almost never called out.
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Imagine being so butthurt about purple hair that you're still bitching about it a year later.
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pikachupwnage posted...

True. But one does need less education to teach than to be a surgeon or lawyer and paying teachers as much as those wills absolutely not be sustainable.

Not necessarily true, you need a masters for NY state, one might compare masters to law school.
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They've had some interesting ideas this season, but their refusal to do continuation episodes has meant that they clearly haven't had enough time to explore them. Almost every episode this season left me with the feeling "that could have been really cool if they didn't rush the hell out of the conclusion".
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Personally, it's not that I necessarily think teachers are underpaid, but I think we should be paying teachers more so that those who are competitive in other fields are lured into the profession. If education up to high school is supposed to provide people the appropriate tools to approach our world in a guided manner, it is currently failing. Better teachers and better education is what we need.
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Super Saiyan 3 Goku posted...

DevsBro posted...

Super Saiyan 3 Goku posted...

I don't think a salary of $60k for a teacher coming off a 4-year degree sounds too bad.

That's average though, not just across the country but across levels of experience too.

I passed $60k three years into my career and I live in Alabama.

Cost of living factors in too, right? $60k in Alabama takes you much farther than the $40k in Boston I was on some years ago.

Any time there's a discussion of salary, where you live plays just as much of a role if not more.

Though, unless there's extremely disproportionate representation of certain careers in certain areas, comparisons of averages essentially take care of that.
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My guess is that it's more likely just normal wear and tear of a set of communal washer and dryers.
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Trash opinion lol
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I look forward to the BMJ Christmas articles every year. Always a hearty hoot.
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Tyranthraxus posted...

COVxy posted...

I know lots about brains, but that's about it.

Your brain made you tell us this.

Jokes on you, I'm only made of ganglia.
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I know lots about brains, but that's about it.
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RiderofHogs posted...

COVxy posted...

And how exactly does the race of the bullies have anything to do with that?

Lol, but if it had been white kids you know damn well it would be a huge issue.

It's a huge issue either fucking way.
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Sad_Face posted...

COVxy posted...

Holy fuck at anyone thinking that the insults indicate race in any meaningful way, or even that it fucking matters. Holy shit, gain some perspective.

It does matter. How else are you supposed to make changes? By telling kids "it's wrong to bully" or "You shouldn't say such things!"? They'll still be thinking those lines which will influence their actions. So you have to understand their thoughts, only then can you influence them to change their behavior and atmosphere so you don't have to worry about it again.

And how exactly does the race of the bullies have anything to do with that? At best, it comes off of a desperate cry of "it wasn't us whites doing the bullying, it was the blacks being racist!" It's honestly a little fucked up that the line of inquiry is just accepted as normal.
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Holy fuck at anyone thinking that the insults indicate race in any meaningful way, or even that it fucking matters. Holy shit, gain some perspective.
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I usually end up with a new view of the problem I'm working on after I start writing it up.
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My guess is that dreams are just a by-product of other neurobiological processes such as memory consolidation and "clean-up routines".
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You didn't even put in any effort there, eh?
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This is code for "be tolerant of my intolerance!"
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The advantages of being untethered to a cable are surprisingly appealing. Especially when doing chores and wanting to watch a show in the background or something. My favorite use of bluetooth headphones is watching tv on my phone while doing dishes.
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WinterFestival posted...

COVxy posted...

I think you don't understand individuation if you think it is the opposite if relativism lol

No, but relativism prevents fair treatment

I think you're trying to say something entirely different than the jargon you use.

You want to say true fairness is exact and equal treatment. Of course, there's obvious reasons why this isn't true. But i think that's all you're trying to say.
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I think you don't understand individuation if you think it is the opposite of relativism lol
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Not my fault, you refused to tell me lol.
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Just have little patience for people who assume they know better than the people who spend their entire lives studying this shit lol.
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P4wn4g3 posted...

You could try not acting like an ass.

Not every opinion is equal, and not all implications deserve to be left uncovered.
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