Current Events > Coronavirus 23: No Title

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CobraGT
10/27/20 11:16:17 PM
#354:


I really had trouble with that link. Urhc show digital subscriber and page kept cycling me through sign in (posting from nytimes link above)

Some Covid Survivors Have Antibodies That Attack the Body, not Virus
New research found autoantibodies similar to those in lupus and rheumatoid arthritis patients. But patients may also benefit from treatments for those autoimmune diseases.

Covid-19 patients were discharged from a temporary hospital in Lima, Peru, last month. The study may help explain why so-called long-haulers continue to experience symptoms long after the virus has left their bodies.Credit...
Martin Mejia/Associated

Some survivors of Covid-19 carry worrying signs that their immune system has turned on the body, reminiscent of potentially debilitating diseases like lupus and rheumatoid arthritis, a new study has found.
At some point, the bodys defense system in these patients shifted into attacking itself, rather than the virus, the study suggests. The patients are producing molecules called autoantibodies that target genetic material from human cells, instead of from the virus.
This misguided immune response may exacerbate severe Covid-19. It may also explain why so-called long haulers have lingering problems months after their initial illness has resolved and the virus is gone from their bodies.
The findings carry important implications for treatment: Using existing tests that can detect autoantibodies, doctors could identify patients who might benefit from treatments used for lupus and rheumatoid arthritis. There is no cure for these diseases, but some treatments decrease the frequency and severity of flare-ups.
Its possible that you could hit the appropriate patients harder with some of these more aggressive drugs and expect better outcomes, said Matthew Woodruff, an immunologist at Emory University in Atlanta and lead author of the work.
The results were reported Friday on the preprint server MedRxiv, and have not yet been published in a scientific journal. But other experts said the researchers who carried out the study are known for their careful, meticulous work, and that the findings are not unexpected because other viral illnesses also trigger autoantibodies.

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CobraGT
10/27/20 11:17:55 PM
#355:


Im not surprised, but its interesting to see that its really happening, said Akiko Iwasaki, an immunologist at Yale University. Its possible that even moderate to mild disease may induce this kind of antibody response.
For months it has been clear that the coronavirus can cause the immune system to run amok in some people, ultimately wreaking more damage to the body than the virus itself. (Dexamethasone, the steroid President Trump took after his Covid diagnosis, has proved effective in some people with severe Covid to tamp down this over-exuberant immune response.)
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Viral infections cause infected human cells to die. Sometimes the cells die a quiet death but sometimes, and especially in the throes of severe infection, they can blow up, strewing their innards. When that happens, DNA, normally cloistered in coiled bundles inside the nucleus, is suddenly scattered and visible.
In the typical response to a virus, cells known as B immune cells make antibodies that recognize pieces of viral RNA from the virus and lock onto them.
But in conditions like lupus, some B cells never learn to do this and instead produce autoantibodies that glom onto DNA debris from dead human cells, mistaking them for intruders. Something similar may be happening in patients with Covid-19, the research suggests.
Anytime you have that combination of inflammation and cell death, there is the potential for autoimmune disease and autoantibodies, more importantly, to emerge, said Marion Pepper, an immunologist at the University of Washington in Seattle.
Dr. Woodruff and his colleagues reported earlier this month that some people with severe Covid-19 also have such unrefined B immune cells. The finding prompted them to explore whether those B cells make autoantibodies.
In the new study, the researchers looked at 52 patients within the Emory health care system in Atlanta who were classified as having either severe or critical Covid-19, but who had no history of autoimmune disorders.
They found autoantibodies that recognize DNA in nearly half of the patients. They also found antibodies against a protein called rheumatoid factor and others that help with blood clotting. Among the top half of the most seriously ill patients, more than 70 percent had autoantibodies against one of the targets tested, Dr. Woodruff said.
Its not just that these patients have an autoimmune-like immune response, he said. Its that those immune responses are coupled with actual true testable clinical auto-reactivities.
Some of the autoantibodies the researchers identified are associated with blood flow problems, noted Ann Marshak-Rothstein, an immunologist and lupus expert at the University of Massachusetts, Worcester.
Its very possible that some of the coagulation issues that you see in Covid-19 patients are being driven by these kinds of immune complexes, she said.
If the autoantibodies do turn out to be long-lasting, she said, they may result in persistent, even lifelong, problems for Covid-19 survivors.
You never really cure lupus they have flares, and they get better and they have flares again, she said. And that may have something to do with autoantibody memory.
Dr. Marshak-Rothstein, Dr. Iwasaki and dozens of other teams are closely studying the immune response to the coronavirus. Given the ease of testing for autoantibodies, it may soon become clear whether the antibodies were identified only because the researchers went looking for them, or whether they represent a more permanent alteration of the immune system.
Its not clear to me what it all means at this point, Dr. Pepper said. Its going to take a little bit of time to understand if this is something thats going to lead to downstream pathology.


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littlebro07
10/28/20 3:15:52 PM
#356:


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LameFAQs
10/28/20 3:17:04 PM
#357:


littlebro07 posted...
https://twitter.com/BNODesk/status/1321530663644942344?s=19

Is it really a lockdown if schools are still operating?
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littlebro07
10/28/20 3:19:35 PM
#358:


LameFAQs posted...
Is it really a lockdown if schools are still operating?

Yeah that's pretty odd. Unless they're going to 100% online?

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DoctorPiranha3
10/28/20 3:38:49 PM
#359:


How long until america locks down again
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Returning_CEmen
10/28/20 3:49:29 PM
#360:


DoctorPiranha3 posted...
How long until america locks down again
Months If Biden wins the election
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LameFAQs
10/28/20 3:59:11 PM
#361:


I dont see them ever doing a nation wide lockdown. Probably just in the biggest hotspots, only once their hospitals start filling up.
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CobraGT
10/28/20 4:05:27 PM
#362:


littlebro07 posted...
https://twitter.com/BNODesk/status/1321530663644942344?s=19


LameFAQs posted...
Is it really a lockdown if schools are still operating?

As dumb as this is, it would be even dumber to try to close the schools.

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DundiesAward
10/28/20 4:06:28 PM
#363:


Returning_CEmen posted...
Months If Biden wins the election

If you talk about US as a whole sure. But Governors could lock down their states at any time.

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Black Pope
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DundiesAward
10/28/20 8:11:05 PM
#364:


Looks like India and Brazil have flatten their curves. So all eyes back on US if they weren't already for the high case numbers.

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Black Pope
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kyujo
10/28/20 8:14:52 PM
#365:


kyujo posted...
We denied Brazil the #1 spot, we can do it again
Sad we actually went for it

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CobraGT
10/28/20 10:56:56 PM
#366:


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kingdrake2
10/28/20 11:07:39 PM
#367:


oregon is getting pretty bad.

average case rate in the 400's.
alot of it in multnomah.
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Returning_CEmen
10/29/20 3:05:47 AM
#368:


Ive had a cold for a week now and today I went to the urgent care and they gave me a COVID-19 test. Wasnt so bad, they swabbed both nostrils and it actually made them feel better. Ill find out my results in 3-4 days
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Bishop9800
10/29/20 3:48:50 AM
#369:


Returning_CEmen posted...
Ive had a cold for a week now and today I went to the urgent care and they gave me a COVID-19 test. Wasnt so bad, they swabbed both nostrils and it actually made them feel better. Ill find out my results in 3-4 days


Keep us updated.


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There are enough attention whores on CE as it is.
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LameFAQs
10/29/20 12:22:11 PM
#370:


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DoctorPiranha3
10/29/20 1:03:22 PM
#371:


Masks and preventive measures in public spaces are pointless if people are just gonna hang around their family and friends like normal. Westerners aren't isiolating like they are in Asia. All it takes is a three week shutdown like Australia had and this shit would be over with.
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PatrickMahomes
10/29/20 1:10:01 PM
#372:


DoctorPiranha3 posted...
Masks and preventive measures in public spaces are pointless if people are just gonna hang around their family and friends like normal. Westerners aren't isiolating like they are in Asia. All it takes is a three week shutdown like Australia had and this shit would be over with.
I mean yes this is all it takes, but even if it's put into place by the federal government (it won't be), people won't follow it regardless. It's pointless to try. And comparing to Austrailia/New Zealand in terms of population and density is just a futile case to try and pitch.

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DoctorPiranha3
10/29/20 1:30:03 PM
#373:


PatrickMahomes posted...
I mean yes this is all it takes, but even if it's put into place by the federal government (it won't be), people won't follow it regardless. It's pointless to try. And comparing to Austrailia/New Zealand in terms of population and density is just a futile case to try and pitch.
What about Taiwan, Japan, Korea etc. far more densely populated. Are not getting hammered.
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PatrickMahomes
10/29/20 1:40:34 PM
#374:


DoctorPiranha3 posted...
What about Taiwan, Japan, Korea etc. far more densely populated. Are not getting hammered.
I didn't say anything about some Asian countries' success with the virus. They have done a great job (although two of those three are tiny islands which is certainly far easier to contain than a typical landlocked country)

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kingdrake2
10/29/20 1:42:20 PM
#375:


DoctorPiranha3 posted...
Japan


i know japan takes it's seriously to the highest level. they don't play with that shit (much more than the US).
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DoctorPiranha3
10/29/20 1:42:56 PM
#376:


PatrickMahomes posted...
I didn't say anything about some Asian countries' success with the virus. They have done a great job (although two of those three are tiny islands which is certainly far easier to contain than a typical landlocked country)
I think you're overblowing the population density thing. Australia is very densely populated into a very small region. Yes most of the country is barren. But that one area successfully locked down.
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Mizznox
10/29/20 9:14:00 PM
#377:


Mizznox posted...
Someone at my work tested positive. It's someone in our other building next door, in a department I don't really interact with, and I haven't felt sick, but they've sent everyone home and are getting testing scheduled for tomorrow. Fun fun fun.

So finally a real update. As of this morning I'd heard we were up to 3 positives, but about an hour ago the city posted that my work had seen 11 cases so far with ~half of us tested (~65 employees) - presumably the half that work in that store, I haven't heard anything more about potential close contact with my store even though the jump seems inevitable. Finally just got my test done, expected 3-5 days for results :/
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kingdrake2
10/29/20 9:35:47 PM
#378:


the scenario is starting. 576 new cases within oregon today.
i'm fucked most of all.
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littlebro07
10/29/20 9:40:44 PM
#379:


Two of my employees had to be sent home today for cold symptoms. Waiting to hear back on their test results.

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Returning_CEmen
10/30/20 11:28:09 AM
#380:


My test results came back negative

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littlebro07
10/30/20 2:12:18 PM
#381:


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PatrickMahomes
10/30/20 2:14:34 PM
#382:


littlebro07 posted...
https://twitter.com/BNODesk/status/1322239718197780480?s=19
god i love a solid belgian waffle with high quality pure maple syrup and bacon bits

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6_7__8910
10/30/20 2:30:28 PM
#383:


Which countries are on lockdown now?
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LameFAQs
10/30/20 4:25:09 PM
#384:


My local supermarkets have started limiting paper towels and toilet paper again. Good to know we regressed back to that part of the pandemic again.
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littlebro07
10/30/20 4:40:14 PM
#385:


https://twitter.com/BNODesk/status/1322274997851795469?s=19

Well

It's nice to see that Americans aren't the only stubborn assholes

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DoctorPiranha3
10/30/20 4:43:25 PM
#386:


LameFAQs posted...
My local supermarkets have started limiting paper towels and toilet paper again. Good to know we regressed back to that part of the pandemic again.
Same at the local ones here.

littlebro07 posted...
https://twitter.com/BNODesk/status/1322274997851795469?s=19

Well

It's nice to see that Americans aren't the only stubborn assholes
Tbh Europe was praised in the beginning, but they weren't really much better. The locked down more uniformly at the beginning while America didn't, that's why summer was bad for Ametica. It took them longer to adapt wearing facemasks. Summer was completely normal for them, they thought they had it beat and Americans are dumb.
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kyujo
10/30/20 5:14:24 PM
#387:


littlebro07 posted...
Two of my employees had to be sent home today for cold symptoms. Waiting to hear back on their test results.
We've got at least 3 in the office coughing all day, wish we would do this

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kingdrake2
10/30/20 5:18:41 PM
#388:


DoctorPiranha3 posted...
Same at the local ones here.


they always had a tp restriction when they came back into stock. same on instant noodles.
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littlebro07
10/30/20 6:24:31 PM
#389:


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kingdrake2
10/30/20 6:25:29 PM
#390:


littlebro07 posted...
Ah shit


the whole region is locked down. no escape.
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DoctorPiranha3
10/30/20 7:08:17 PM
#391:


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littlebro07
10/30/20 7:21:48 PM
#392:


DoctorPiranha3 posted...
https://twitter.com/BNODesk/status/1322313748267307008

Turning the corner

"We're turning the corner, folks, and believe me it is the biggest most beautiful corner anyone's ever seen in the history of the United States of America. Everyone's telling me "we've never seen corners like this" and the Democrats have small corners. The smallest corners ever. You need a magnifying glass to see these corners! Nancy Pelosi wouldn't give the American people stimulus checks. I wanted a bill with just checks, I said "let's get these people stimulus checks, the biggest stimulus checks in history" and the Democrats said "we don't want to give them checks!" and I'll tell you all this corner is so beautiful, so big, and we're coming around it, folks."

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DundiesAward
10/30/20 7:28:18 PM
#393:


https://twitter.com/BNODesk/status/1322316725438849026

US coming for India's record.

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Black Pope
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kingdrake2
10/30/20 9:42:58 PM
#394:


oregon hit 600 new cases now :(.
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CobraGT
10/30/20 9:55:23 PM
#395:


kingdrake2 posted...
they always had a tp restriction when they came back into stock. same on instant noodles.


Restrictions on instant noodles? Now you are scaring me. I wish I had laid in a supply. Of course Caribbean Dreams Cock Soup only takes 12 minutes to make but I have a pot to clean.

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littlebro07
10/30/20 9:56:03 PM
#396:


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DevilZhouYu
10/30/20 9:57:42 PM
#397:


India eat your heart out.
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CobraGT
10/30/20 10:00:34 PM
#398:


maga

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DoctorPiranha3
10/30/20 10:02:48 PM
#399:


It'll be gone by Easter
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RIPVyseCity
10/30/20 10:09:27 PM
#400:


DoctorPiranha3 posted...
It'll be gone by Easter
Easter 2022?
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yunalenne10
10/30/20 10:11:35 PM
#401:


Still can't believe I got tested positive 2 days ago...

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"The more beautiful and pure a thing is, the more satisfying it is to corrupt it." - Rule 43
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6_7__8910
10/30/20 10:11:39 PM
#402:


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kingdrake2
10/30/20 10:12:51 PM
#403:


CobraGT posted...
Now you are scaring me


safeway policy. could go into lets say dollar tree or grocery outlet. there isn't a restriction on noodles.
if you have other stores. i'm sure they're only enforcing limits on some things but not noodles.
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