Poll of the Day > My second dose symptoms are a lot better than the first.

(+) Yeah! (+)

Like after the first dose I had a killer headache, nausea, fever, and had issues seeping due to trying to solve some random problem in my head all night.

This time I just... have a fever.

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You're just now getting your second? How lazy are you?

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God damn ziggi.
It all makes so much sense now.

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Kinda weird, most people I've known who took the 2-dose ones got hammered by the second dose... although I think most of them went with Pfizer so the Moderna probably sucks less.

Personally, given that the Janssen is a thing, I'm not sure why anybody goes with the other ones. A one-dose vaccine is a lot less hassle and the side effects are milder

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Zeus posted...

Moderna probably sucks less

I definitely felt like I was falling ill the morning after the second dose, moreso than the day after the first.
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I had about the same reaction to both doses. Mostly just a sore arm and a bit of a funky feeling the day of, but nothing else.

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dragon504 posted...

I had about the same reaction to both doses. Mostly just a sore arm and a bit of a funky feeling the day of, but nothing else.

This except mine was awfully sore, my arm felt like it was almost paralysed and it hurt to move more than my fingers.

Judgmenl posted...

God damn ziggi.
It all makes so much sense now.

Sorry, your sweet burn was modded before I got to see it, ok?

I'm sure you got me real good, though, ok?

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Zeus posted...

Personally, given that the Janssen is a thing, I'm not sure why anybody goes with the other ones. A one-dose vaccine is a lot less hassle and the side effects are milder

The two dose shots have higher efficacy than J&J. Also, if you got one back when they were harder to get, most people including myself have said they just got whatever was the first one they could get. Even now it's probably kind of a hassle to find a particular one, you don't really know what the pharmacy will have available til you sign up

I took a couple hour nap and watched some anime. Feel mainly ok now.
Just a fever. and I got Pfizer.
After the first dose I was in bed the majority of the day.

Aculo posted...

Sorry, your sweet burn was modded before I got to see it, ok?

I'm sure you got me real good, though, ok?

I deleted it, ok?
I don't get moderated.

CoorsLight posted...

Even now it's probably kind of a hassle to find a particular one, you don't really know what the pharmacy will have available til you sign up

Place I went to had all 3 afaik.

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Judgmenl posted...

I deleted it, ok?
I don't get moderated.

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I don't know why you would doubt that?

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My first and second dose only gave me a sore arm.

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CoorsLight posted...

The two dose shots have higher efficacy than J&J.

Based on what?

CoorsLight posted...

Even now it's probably kind of a hassle to find a particular one, you don't really know what the pharmacy will have available til you sign up

Ehhhh, I assume you can probably just google pharmacies to find out (because that's what I did, and I imagine it's the same in every state), or even call. I had to go out of my way to find the Janssen, but it wasn't super hard. It was worth it to the extent I had fewer side-effects, but honestly I don't put much faith in the vaccines over my natural immunity since I almost never get sick.

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My second dose symptoms were worse, but not by much.
The night that I got it, I was really sore and tired, but it went away when I woke up the next morning.

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Judgmenl posted...

I don't know why you would doubt that?

Oh interesting, I didn't realize that one screen showed your entire moderation history, ok?

I realized you were slow, judg... But I mean, come on, ok?

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Only way you're getting that info is if Lan or someone tells you.
I was last moderated so long ago I don't have a moderation history.
Last time I got suspended/warned was probably the Kana event.

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Judgmenl posted...

Only way you're getting that info is if Lan or someone tells you.

I don't want it. I didn't believe you when you said you don't get moderated, and lies and behold...

Judgmenl posted...

I was last moderated so long ago...

lol Still a lie, and yet the story chances so easily, ok?

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Pfizer-Moderna here (as of yesterday afternoon), second dose has been much worse. First dose was just a sore arm for a couple days. This time, my arm is much more sore, I've been generally very fatigued, woke up today aching pretty much all over, and have cycled between feeling feverish and feeling nauseous all day. It's improving now, so I'm hoping I should be more or less alright tomorrow, but I've been out of commission for most of the day.

Zeus posted...

Based on what?

https://gamefaqs.gamespot.com/boards/3-poll-of-the-day/79550498/955867031

You've already asked that question and had it answered. Granted, that answer just covers the first dose efficacy of Pfizer/Moderna, but I think it's common enough knowledge that the second shot works even better that I don't need to spell that out for you.

Zeus posted...

honestly I don't put much faith in the vaccines over my natural immunity since I almost never get sick.

That's... not how anything about immunology works at all.

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adjl posted...

https://gamefaqs.gamespot.com/boards/3-poll-of-the-day/79550498/955867031

You've already asked that question and had it answered. Granted, that answer just covers the first dose efficacy of Pfizer/Moderna, but I think it's common enough knowledge that the second shot works even better that I don't need to spell that out for you.

Didn't see it. (Keep in mind I have a *lot* of notifications at any given moment; last Friday I was up to 120 notifications.) However, more importantly, the data provided seems to be based on *old* studies. And that's been the biggest issue when people have been trying to compare the mRNA vaccines to the viral vector vaccines, because the studies that are often STILL being cited are much older when there was less variation. Hell, one of your links was published around the time the Delta was first appearing. You *really* can't rely on old research with something like this, which is why the newer research is what really matters.

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I had no issues with my first dose so the second one shouldn't be a problem. Maybe next month I'll be told I can get that as we must wait 12 weeks between doses.

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Zeus posted...

Kinda weird, most people I've known who took the 2-dose ones got hammered by the second dose... although I think most of them went with Pfizer so the Moderna probably sucks less.

Personally, given that the Janssen is a thing, I'm not sure why anybody goes with the other ones. A one-dose vaccine is a lot less hassle and the side effects are milder

Blood clots.
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Go with the one that work good or go with the one that work bad.
Your choice. They're both free.

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Zeus posted...

Didn't see it. (Keep in mind I have a *lot* of notifications at any given moment; last Friday I was up to 120 notifications.) However, more importantly, the data provided seems to be based on *old* studies. And that's been the biggest issue when people have been trying to compare the mRNA vaccines to the viral vector vaccines, because the studies that are often STILL being cited are much older when there was less variation. Hell, one of your links was published around the time the Delta was first appearing. You *really* can't rely on old research with something like this, which is why the newer research is what really matters.

Alright, so let's find some more recent data on Delta-specific efficacy:

Pfizer (July 7):
https://www.ctvnews.ca/health/coronavirus/pfizer-vaccine-protection-takes-a-hit-as-delta-variant-spreads-israeli-government-says-1.5499682

UK: 79% in June, 96% this month
Canada: 87% a week ago
Israel: 64% in June, with the caveat that it was too soon to say anything definitive

Moderna (July 8):
https://www.businessinsider.com/delta-variant-covid-vaccine-effectiveness-protection-pfizer-moderna-astrazeneca-2021-7

Canada: 72% after one dose (insufficient data to determine 2-dose efficacy), a week ago

Janssen (July 1):
https://www.nbcboston.com/news/local/pfizer-moderna-jj-vaccines-efficacy-as-delta-variant-concerns-rise/2419162/

US: 60% (no date)

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Huh. Look at that. Available estimates fail to disprove the hypothesis that the Janssen shot is less effective than the two-dose ones, even against the delta variant. Heck, as a bonus, there's talk of recommending that J&J recipients get an mRNA booster shot for added protection (https://www.reuters.com/business/healthcare-pharmaceuticals/booster-may-be-needed-jj-shot-delta-variant-spreads-some-experts-already-taking-2021-06-25/), though that hasn't solidified into anything concrete yet. And then there's the well-established fact that it's less effective overall than the others, even comparing first doses. Naturally, all of these are still fairly preliminary estimates, so they may change (lambda may also shake things up), but the alternative is a baseless random guess, which is hardly more credible.

As I've said on several occasions now, I wish J&J were a better option than it is, given the convenience (the blood clot issue generally seems to be worse than the myocarditis one, but both are pretty negligible risks), but it just isn't. It's a whole lot better than nothing, and that makes it a great choice for regions where the infrastructure isn't available to transport and store the others, but if alternatives are available, you're going to be better off with them. There's very little point in actively seeking out J&J unless you need to travel on such short notice that waiting the ~6 weeks a two-dose schedule requires isn't feasible (though these vaccines have been available for long enough now that that's just a failure of planning on your part).

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