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TopicImagine avoiding a vaccine because you're scared of your arm being sore
Clench281
07/29/21 7:13:04 PM
#22:


DrPrimemaster posted...
What about someone who had already gotten covid and reacted semi bad to it and doesn't want to get the vaccine because they feel they're already immune and don't want to go through the effects again (supposedly you react worse if you've already had covid)?

You would think someone who had a severe covid case would want to prevent it from happening again. And the best way to do so is with the mRNA vaccine.

Natural immunity to covid will consist of antibodies to all random surface proteins of the virus. Many of which are perfectly free to evolve without any detrimental fitness effects, allowing it to potentially evade the immune system.

The vaccine specifically causes antibody production targeting spike protein, most importantly to the receptor binding domain, which is under extremely strong selection. This region cannot mutate much, because its shape confers its ability to bind and enter human cells. Thus, immunity from the vaccine is expected to be more robust in the face of evolving strains.

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