Current Events > Pfizer's vaccine immunity falls off after two months!

(+) Yeah! (+)

https://www.cnn.com/2021/10/06/health/pfizer-vaccine-waning-immunity/index.html

Two months...

"Two real-world studies published Wednesday confirm that the immune protection offered by two doses of Pfizer's Covid-19 vaccine drops off after two months or so, although protection against severe disease, hospitalization and death remains strong.

The studies, from Israel and from Qatar and published in the New England Journal of Medicine, support arguments that even fully vaccinated people need to maintain precautions against infection.
One study from Israel covered 4,800 health care workers and showed antibody levels wane rapidly after two doses of vaccine "especially among men, among persons 65 years of age or older, and among persons with immunosuppression."

"We conducted this prospective longitudinal cohort study involving health care workers at Sheba Medical Center, a large tertiary medical center in Israel," Sheba's Dr. Gili Regev-Yochay and colleagues wrote.

The researchers noted that levels of so-called neutralizing antibodies -- the immune system's first line of defense against infection -- correlate with protection against infection, but for this study they studied only antibody levels.

"Published work about many vaccines, such as those against measles, mumps, and rubella, has shown a small decrease each year of 5 to 10% in the neutralizing antibody levels," they wrote. "We found that a significant and rapid decrease in humoral response to the BNT162b2 vaccine was observed within months after vaccination."

The study also indicated that immunity for people who get vaccinated after natural Covid-19 infection lasts longer. It's especially strong for people who recovered from infection and then got vaccinated, also. "Overall, the accumulating evidence from our study and others shows that long-term humoral response and vaccine effectiveness in previously infected persons were superior to that in recipients of two doses of vaccine," they wrote.

A second study from Qatar looked at actual infections among the highly vaccinated population of that small Gulf nation. People there mostly got Pfizer/BioNTech's vaccine, also known as BNT162b2.

"BNT162b2-induced protection against infection builds rapidly after the first dose, peaks in the first month after the second dose, and then gradually wanes in subsequent months," Laith Abu-Raddad of Weill Cornell Medicine-Qatar and colleagues wrote. "The waning appears to accelerate after the fourth month, to reach a low level of approximately 20% in subsequent months," they added.

Nonetheless, protection against hospitalization and death stayed at above 90%, they said.
The waning protection may involve behavior, they noted. "Vaccinated persons presumably have a higher rate of social contact than unvaccinated persons and may also have lower adherence to safety measures," they wrote. "This behavior could reduce real-world effectiveness of the vaccine as compared with its biologic effectiveness, possibly explaining the waning of protection."

But it's a signal that countries should prepare for fresh surges of Covid-19. "These findings suggest that a large proportion of the vaccinated population could lose its protection against infection in the coming months, perhaps increasing the potential for new epidemic waves," they wrote.

Pfizer has been arguing that immunity from the first two doses of its vaccine begins to wear off after a few months. Last month, Pfizer won authorization from the US Food and Drug Administration for booster doses of its vaccine for some six months after people finish their first two doses.

The US Centers for Disease Control and Prevention recommended that people older than 65, people with conditions making them more susceptible to getting seriously ill with breakthrough infections, and people at high risk of infection such as health care workers and prison inmates get boosters."

Israel has been boosting its entire population and now says it will require people to have had a third shot to be considered fully vaccinated.

In the United States, more than 6 million people have received a third dose of vaccine and average the pace of booster shots is higher than the rate of people getting vaccinated for the first time."

Cocytus posted...

Nonetheless, protection against hospitalization and death stayed at above 90%, they said.

---

I'm glad I got the moderna one :v

Cocytus posted...

although protection against severe disease, hospitalization and death remains strong.

Cocytus posted...

Nonetheless, protection against hospitalization and death stayed at above 90%, they said.
The waning protection may involve behavior, they noted. "Vaccinated persons presumably have a higher rate of social contact than unvaccinated persons and may also have lower adherence to safety measures," they wrote. "This behavior could reduce real-world effectiveness of the vaccine as compared with its biologic effectiveness, possibly explaining the waning of protection."

Antivaxxers: If it's not 100% it's 0%!

---

Ah just like armor, people do more stupid things when protected.

---

There was a virologist who tested his antibody count and he had a steady decline, his last test showed a 33% drop in antibodies over 5 months. He speculated that we will likely need yearly booster shots if we want to maintain antibody levels and that the vaccine will be improved over time.

---

Welp, guess we all better mask the fuck up, eh TC?

---

ok and? just get your booster shot

---

DarkRoast posted...

Antivaxxers: If it's not 100% it's 0%!

I'm not an antivaxxer. I'm just passing on some news. I myself am vaccinated, Moderna, since April.

Tappor posted...

ok and? just get your booster shot

They barely started booster shots.

although protection against severe disease, hospitalization and death remains strong.

Not really concerning is it?

---

IHeartRadiation posted...

Not really concerning is it?

To know that protection starts to fall away in two months is concerning, particularly for special populations.

I got the Johnson and Johnson vax about four months ago and Im pretty sure I had COVID last week. I tested negative but it felt like the first time I had it.

Just my experience.

---

DarkRoast has quickly become my favorite poster

---

IHeartRadiation posted...

Not really concerning is it?

You can still get very sick and make others sick.
In addition, vaccinated people getting sick is a ticking time bomb in regards to mutations.

LightHawKnight posted...

Ah just like armor, people do more stupid things when protected.

I wouldnt say people are doing stupid things. Theyre doing things theyve been doing their whole life because they thought they were good.

---

I got both the Pfizer and Moderna. I have best of both worlds I guess?

MrDrMan posted...

I got the Johnson and Johnson vax about four months ago and Im pretty sure I had COVID last week

i got that same vaccine. just playing careful on what i do on a daily basis. even if it means crossing to the other side of the street to avoid school kids (they could be infected).

limiting store trips also helps.
---

Lol flopic backfired

---

JustMyOpinion posted...

Unless it's horse paste.

great chance to die. same with huffing hydrogen peroxide.
---

I really hate that exclamation point in the title and what it signifies
---

The best thing to be is antisocial :D

---

BNT162b2-induced protection against infection builds rapidly after the first dose, peaks in the first month after the second dose, and then gradually wanes in subsequent months," Laith Abu-Raddad of Weill Cornell Medicine-Qatar and colleagues wrote. "The waning appears to accelerate after the fourth month, to reach a low level of approximately 20% in subsequent months," they added.

Nonetheless, protection against hospitalization and death stayed at above 90%, they said.
The waning protection may involve behavior, they noted. "Vaccinated persons presumably have a higher rate of social contact than unvaccinated persons and may also have lower adherence to safety measures," they wrote. "This behavior could reduce real-world effectiveness of the vaccine as compared with its biologic effectiveness, possibly explaining the waning of protection.

Honestly I didnt know it provided immunity I thought it just helped fight it off easier.

---

Mistere Man posted...

Honestly I didnt know it provided immunity I thought it just helped fight it off easier.

There's been a strong right-wing narrative that "you can spread it anyway" even when vaxxed, which seems to suggest no immunity. That is not true.

Essentially it is all the same mechanism, but to stop transmission you need the immune response to rapidly kick in, and it looks like immune response just slows over time when not reintroduced to the virus.

---

WeeWeiWiiWie posted...

There's been a strong right-wing narrative that "you can spread it anyway" even when vaxxed, which seems to suggest no immunity. That is not true.

Essentially it is all the same mechanism, but to stop transmission you need the immune response to rapidly kick in, and it looks like immune response just slows over time when not reintroduced to the virus.

Interesting, and thank you.

On a side note have they done this kind of test on moderna? I am curious about its immunity % numbers if there are any.

---

Crescente posted...

I got both the Pfizer and Moderna. I have best of both worlds I guess?

Did you really?

Putting all this other stuff aside and focusing on the immunity drop, I will get my boosters in the future but I'm concerned because I know quite a few vaccinated people that have no interest in getting them in the future

---

BignutzisBack posted...

I know quite a few vaccinated people that have no interest in getting them in the future

you'll have to make that decision to be around them in the future if they choose not to take something that will potentially save them from a ventilator or worse.
---

Vaccines are the rough analogue of a "don't accept checks from this person" note taped to a cash register. It's not going to keep that idiot from coming in, but it warns the clerk what to look for.

WingsOfGood posted...

You can still get very sick and make others sick.
In addition, vaccinated people getting sick is a ticking time bomb in regards to mutations.

You're also 80% less likely to contract the disease in the first place, so your logic is a bit stupid.

And there is literally no virology logic behind vaccines causing mutations. Mutations are entirely caused by viral replication cycles. In a population 80% less likely to contract the virus, even if the viral loads are similar in the infected, you'll have 80% fewer replications overall.

---