Current Events > Crappy drug Remdesivir is approved and costs a fuck ton

(+) Yeah! (+)

but the FDA approved it, it must be good!!!

Literally $500+ a vial

Physician here.

When the first wave happened, we were literally trying everything we can. The second a trial or new literature was publish saying this particular med worked, we had to jump on it. The fact is, we had no idea how to treat this shit and we had no options.

So yes, so what if FDA approves it, who cares if its expensive? Do you rather be trached, peg'd and live in a nursing home for all your life or pay $500? I rather pay $500.

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https://www.nejm.org/doi/full/10.1056/NEJMoa2007764

Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.

I understand cost complaints but why is it crappy?

Boo science!
Yay grandma's Facebook post!

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megamanfreakXD posted...

Physician here.

When the first wave happened, we were literally trying everything we can. The second a trial or new literature was publish saying this particular med worked, we had to jump on it. The fact is, we had no idea how to treat this shit and we had no options.

So yes, so what if FDA approves it, who cares if its expensive? Do you rather be trached, peg'd and live in a nursing home for all your life or pay $500? I rather pay $500.

lmfao it's not $500 for the entire treatment course

it's not better than placebo

It costs a fortune? Im shocked

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ToPoPO posted...

it's not better than placebo

Based on what?

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$500? That isn't all that bad.

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Pharmacist here.

Yeah, at this point I've probably made hundreds of doses. Treatment course is 5 days - 200mg on day 1, then 100mg daily for 4 additional days.

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Pogo_Marimo posted...

Based on what?

WHO

Super Saiyan 3 Goku posted...

Pharmacist here.

Yeah, at this point I've probably made hundreds of doses. Treatment course is 5 days - 200mg on day 1, then 100mg daily for 4 additional days.

I've also made plenty, it sucks, also my department needs to allow us to snap the vials to the bag with the adaptor

Pogo_Marimo posted...

Based on what?

Earlier studies had showed improved time to recovery. However there is a recent massive meta analysis showing there is no difference in mortality between the placebo and remdesivir group.

That's fine and all, at least now we know and hospital will change their policies and treatment regimen to improve patient care.

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ToPoPO posted...

I've also made plenty, it sucks, also my department needs to allow us to snap the vials to the bag with the adaptor

Really? We have to reconstitute the vial and take out the appropriate overfill from the 250mL bag.

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ImAMarvel posted...

Doesn't it actually cost like $3000 or so altogether? lol what a joke

Probably - it's like 6 vials per treatment course.

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Super Saiyan 3 Goku posted...

Really? We have to reconstitute the vial and take out the appropriate overfill from the 250mL bag.

I only take out overfill from the bag if we're using the reconstituted solution vials, otherwise I just do 20 mL bag NS in each vial and inject contents back into the bag

ToPoPO posted...

I only take out overfill from the bag if we're using the reconstituted solution vials, otherwise I just do 20 mL bag NS in each vial and inject contents back into the bag

How about stability? We have to assign a 4 hour stability but I think recent data shows it can last longer than that.

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Super Saiyan 3 Goku posted...

How about stability? We have to assign a 4 hour stability but I think recent data shows it can last longer than that.

24 hr ref in hood, 4 hour RT if compounded outside for immediate use

Also a doctor

remdesivir reminds me of tamiflu

sort of works

if you die it's not because you did or did not receive it

Mostly all about the $$$$$$$$$$$$$$$ imo

versus, you know, dex or prone venting or something with real science lol

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tote_all posted...

Im confused. Is your original post defending using it back then or now?

I defend the use of it back then and still now depending on hospital policy. The reason is that the only side effect that we are concerned about is drug induced hepatitis, for which the treatment is to stop the medication. So even if it has shown to not work but barely work in other studies, I would still give as we don't actually have any other options right now other than dexamethasone and giving a NOAC for anticoagulation. Whereas HCQ actually has worry some side effects and should be stopped if it doesn't show efficacy.

https://covidprotocols.org/chapters/treatments/#remdesivir-sehwnlybws5f

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You're giving people with COVID NOACs?

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NightingaleMD posted...

You're giving people with COVID NOACs?

Or lovenox.

Our mortality rates were lower compared to other hospitals and we think it is because we treat then with NOACS due to the hypercoagulability state that causes them to code from PEs.

From NIH

Continuing anticoagulation with a Food and Drug Administration-approved regimen for extended VTE prophylaxis after hospital discharge can be considered in patients who are at low risk for bleeding and high risk for VTE, as per the protocols for patients without COVID-19 (see text for details on defining at-risk patients) (BI).

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I mean

Are you giving them DOACs prophylactically or only if they have DVT/PE

not heard of giving them prophylactically

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NightingaleMD posted...

I mean

Are you giving them DOACs prophylactically or only if they have DVT/PE

not heard of giving them prophylactically

Prophylaxis

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