Current Events > Even moderate alcohol consumption correlated to hippocampal atrophy

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Darkman124
06/08/17 8:35:03 AM
#1:


http://www.bmj.com/content/357/bmj.j2353

Compared with abstinence, higher alcohol consumption was also associated with increased odds of abnormally rated hippocampal atrophy (defined as score >0 on Scheltens visual rating scale; table 2). This was a dose dependent effect. The highest odds were in those drinking in excess of 30 units a week (odds ratio 5.8, 95% confidence interval 1.8 to 18.6; P<0.001), but odds of atrophy were higher compared with abstinence even in those drinking at moderate levels of 7-<14 units a week (3.4, 1.4 to 8.1; P=0.007). There was no protective effect (that is, reduced odds of atrophy) with light drinking (1-<7 units a week) over abstinence. Findings were similar in subanalyses of men alone but not in the smaller subgroup of women. The risk of right sided hippocampal atrophy was significantly greater at >14 alcohol units a week compared with abstinence, but for left sided atrophy at only >30 units a week.


Note: 1 pint beer = 3 alcohol units; 1 glass wine = 2.4 alcohol units

This makes me rethink my life.
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Johnny_Nutcase
06/08/17 8:36:47 AM
#2:


Ehhh who gives a shit. Hell, i'll drink to that.
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COVxy
06/08/17 8:40:39 AM
#3:


Always caution any results regarding atrophy or volume changes in MRI. The biological substrate of these changes is impossible to determine. Could be cell death, but could also be reductions dendritic aborization or even loss of glial cells.
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Omega Hunter
06/08/17 8:42:07 AM
#4:


Who cares. No one drinks alcohol because its got the benefits of kale juice. People who drink have made the determination that the recreational/pleasure value exceed the harm to their health and there is nothing wrong with that. I make that decision everytime i have a burger and fries or play video games until 2 AM and only get 4 hours of sleep. My father never drank alcohol ever, hes been sick his whole life with high blood pressure issues and diabetes, i drink multiple times a week and am in great health (he was sick by my age). Its not like not having a drink guarantees you good health.
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DidoIrrumata
06/08/17 8:43:40 AM
#5:


Who cares about the hippocampus anyway?
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Darkman124
06/08/17 8:45:48 AM
#6:


COVxy posted...
Always caution any results regarding atrophy or volume changes in MRI. The biological substrate of these changes is impossible to determine. Could be cell death, but could also be reductions dendritic aborization or even loss of glial cells.


they didn't exclusively look at that.


Higher alcohol consumption over the study predicted faster decline on lexical fluency but not semantic fluency or word recall (fig 6). Those drinking 7-<14, 14-<21, and >21 units a week declined faster in terms of lexical scores than abstainers. This effect was independent of age, sex, premorbid IQ, education, social class, and Framingham stroke risk score.The size of the difference can be interpreted as follows: people drinking 7-<14 units experienced a 0.5% greater reduction from their baseline in lexical fluency per year (14% over 30 years), those drinking 14-<21 units 0.8% greater per year (17% over 30 years), and those drinking >21 units 0.6% per year (16% over 30 years) than abstainers (appendix table F). Though the three categories of higher consumption (7-<14, 14-<21, and >21 units/week) showed significantly greater decline than abstainers, the only significant difference in trends between these three groups was between those drinking 14-21 units and those drinking 7-14 units (14-21 units experience 0.3% faster decline per year; P=0.02). There was no evidence to support light drinkers being relatively protected from cognitive decline compared with abstainers.


DidoIrrumata posted...
Who cares about the hippocampus anyway?


people who don't want to get Alzheimer's disease
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COVxy
06/08/17 8:47:22 AM
#7:


DidoIrrumata posted...
Who cares about the hippocampus anyway?


H.M. would have had he been able to remember he didn't have them.
*buh dum pish*

(Though his case is actually much more complicated than that, despite most reporting referencing it as a specific ablation of bilateral hippocampi)
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COVxy
06/08/17 8:50:18 AM
#8:


Darkman124 posted...
they didn't exclusively look at that.


You would expect functional consequences with any of the scenarios I brought up. The main point is that people hear volume change and often assume neural cell death (even people publishing, at times).
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Darkman124
06/08/17 8:51:55 AM
#9:


COVxy posted...
Darkman124 posted...
they didn't exclusively look at that.


You would expect functional consequences with any of the scenarios I brought up. The main point is that people hear volume change and often assume neural cell death (even people publishing, at times).


this is much more your area of expertise than mine

would a >15% reduction in cognitive function occur in those scenarios?
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COVxy
06/08/17 9:07:37 AM
#10:


No reason to think it's not possible. Keep in mind that the metrics used in this study aren't exactly specific metrics. Usually used for broad strokes measures of cognitive decline in these clinical studies.
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Balrog0
06/08/17 9:13:12 AM
#11:


Haha I knew I was destroying my body already

Really though, sucks but I'm not gonna stop drinkin
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#12
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drunkmuggle
06/08/17 10:14:06 AM
#13:


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ROD
06/08/17 10:16:20 AM
#14:


what are the practical effects of hipoccampal atrophy?
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Dagger32
06/08/17 10:20:16 AM
#15:


I don't know, I know some asshole alcoholics who are in their 80-90s and just won't die and their brains work just fine.
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green butter
06/08/17 10:23:06 AM
#16:


drunkmuggle posted...
alcohol is POISON

durrrrrr look at me, im going to intentionally poison myself and risk death & early onset alzheimers so i can have a shitty time and feel terrible the next morning

if americans spent more time in the House of God praying and less time poisoning themselves so they are able to make fools of themselves in social situations, we would be living in a utopia by now with flying cars
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Darkman124
06/08/17 10:34:11 AM
#17:


ROD posted...
what are the practical effects of hipoccampal atrophy?


alzheimer's
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Haldol
06/08/17 10:45:24 AM
#18:


Omega Hunter posted...
Who cares. No one drinks alcohol because its got the benefits of kale juice. People who drink have made the determination that the recreational/pleasure value exceed the harm to their health and there is nothing wrong with that. I make that decision everytime i have a burger and fries or play video games until 2 AM and only get 4 hours of sleep. My father never drank alcohol ever, hes been sick his whole life with high blood pressure issues and diabetes, i drink multiple times a week and am in great health (he was sick by my age). Its not like not having a drink guarantees you good health.

True but that's just you. Your dad obviously has other factors hurting him, but I can assure he'd be much worse if he had spent his life drinking

Drinking isn't the only thing that can kill you, but it sure isn't harmless. I work in an intensive care unit. I see the effects of alcoholism and drinking almost daily.
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Haldol
06/08/17 10:46:57 AM
#19:


Dagger32 posted...
I don't know, I know some asshole alcoholics who are in their 80-90s and just won't die and their brains work just fine.

They are the exception, not the rule

I know a lot of alcoholics who need a new liver at 40 because they fucked it up drinking all the time
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ROD
06/08/17 11:15:57 AM
#20:


Darkman124 posted...
ROD posted...
what are the practical effects of hipoccampal atrophy?


alzheimer's


DAMN
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ReignFury
06/08/17 11:21:24 AM
#21:


ROD posted...
Darkman124 posted...
ROD posted...
what are the practical effects of hipoccampal atrophy?


alzheimer's


DAMN


but what are the practical effects of hipoccampal atrophy?
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s0nicfan
06/08/17 11:25:33 AM
#22:


green butter posted...
drunkmuggle posted...
alcohol is POISON

durrrrrr look at me, im going to intentionally poison myself and risk death & early onset alzheimers so i can have a shitty time and feel terrible the next morning

if americans spent more time in the House of God praying and less time poisoning themselves so they are able to make fools of themselves in social situations, we would be living in a utopia by now with flying cars


The american spirit put robots on the moon, split the atom, and sequenced the genome. The house of god pushes gays off rooftops.

Wanna hear a fun statistic? Muslims make up 23% of the world's population, but make up only 0.8% of all Nobel science and math winners. Funny how all that prayer and abstinence doesn't seem to be creating scientists.
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EnragedSlith
06/08/17 11:28:04 AM
#23:


s0nicfan posted...
green butter posted...
drunkmuggle posted...
alcohol is POISON

durrrrrr look at me, im going to intentionally poison myself and risk death & early onset alzheimers so i can have a shitty time and feel terrible the next morning

if americans spent more time in the House of God praying and less time poisoning themselves so they are able to make fools of themselves in social situations, we would be living in a utopia by now with flying cars


The american spirit put robots on the moon, split the atom, and sequenced the genome. The house of god pushes gays off rooftops.

Wanna hear a fun statistic? Muslims make up 23% of the world's population, but make up only 0.8% of all Nobel science and math winners. Funny how all that prayer and abstinence doesn't seem to be creating scientists.

Are you actually serious or are you really this dumb?
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s0nicfan
06/08/17 11:29:07 AM
#24:


EnragedSlith posted...
s0nicfan posted...
green butter posted...
drunkmuggle posted...
alcohol is POISON

durrrrrr look at me, im going to intentionally poison myself and risk death & early onset alzheimers so i can have a shitty time and feel terrible the next morning

if americans spent more time in the House of God praying and less time poisoning themselves so they are able to make fools of themselves in social situations, we would be living in a utopia by now with flying cars


The american spirit put robots on the moon, split the atom, and sequenced the genome. The house of god pushes gays off rooftops.

Wanna hear a fun statistic? Muslims make up 23% of the world's population, but make up only 0.8% of all Nobel science and math winners. Funny how all that prayer and abstinence doesn't seem to be creating scientists.

Are you actually serious or are you really this dumb?


I mean... I wasn't being serious because the post I replied to was clearly trolling, but the statistic is real, so take that however you want.
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SpiralDrift
06/08/17 11:33:42 AM
#25:


Glad I've never drunk alcohol.
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chill02
06/08/17 11:35:53 AM
#26:


et tu, booze?
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ManSpread
06/08/17 6:42:43 PM
#27:


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Darkman124
06/09/17 7:21:10 AM
#28:


i blame this for why my memory got worse over the years
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ManSpread
06/10/17 10:24:12 PM
#30:


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southcoast09
06/10/17 10:29:01 PM
#31:


Tip:

Cops are cracking down on people who are legitamately under the legal limit. If you want to drink anything, just don't drive.
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ManSpread
06/10/17 11:44:21 PM
#32:


southcoast09 posted...
Tip:

Cops are cracking down on people who are legitamately under the legal limit. If you want to drink anything, just don't drive.

or just get drunk at home
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Darkman124
06/12/17 7:21:00 AM
#33:


uber makes it pretty easy to do that
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EternalDivide
06/12/17 7:28:15 AM
#34:


Eh. Everything is killing us. Everything causes some disease. So says every new study that comes out and it's been that way for years.
Yes alcohol is bad. In large quantities. Fatty foods are bad. In large quantities.
The key is moderation.

We're all going to die. If a couple of glasses of wine a week and the occasional Five Guys burger takes off a few months I'm more than fine with that trade off.
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Flintgrandad
06/14/17 1:03:43 AM
#35:


Interesting
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drunkmuggle
06/15/17 10:47:44 AM
#36:


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AlephZero
06/15/17 10:50:40 AM
#37:


nice i hope it kills me sooner
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Flintgrandad
06/17/17 2:42:14 AM
#38:


Interesting
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DrizztLink
06/17/17 2:46:51 AM
#39:


Haldol posted...
Dagger32 posted...
I don't know, I know some asshole alcoholics who are in their 80-90s and just won't die and their brains work just fine.

They are the exception, not the rule

I know a lot of alcoholics who need a new liver at 40 because they fucked it up drinking all the time

Hell, a girl who worked at my barber's died of liver failure at like 28 or 30.
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teepan95
06/17/17 3:13:25 AM
#40:


STRAIGHT
EDGE
STRAIGHT
EDGE
STRAIGHT
EDGE

(caps)
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#41
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#42
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FightingGames
06/21/17 1:28:06 AM
#43:


this kills the chad
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ManSpread
06/21/17 1:28:07 AM
#44:


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Flintgrandad
06/23/17 12:49:35 AM
#45:


what is this
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ManSpread
06/23/17 10:27:45 PM
#46:


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Darkman124
06/23/17 10:30:45 PM
#47:


yeah im drunk

got to see jerry at spotted dog brewing co for the first time in like a year

i miss my brewer friends
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Pancake
06/23/17 10:33:11 PM
#48:


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Manocheese
06/23/17 10:35:29 PM
#49:


That's why President Trump is so smart.
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Yaridovich
06/23/17 10:36:47 PM
#50:


DidoIrrumata posted...
Who cares about the hippocampus anyway?


Yeah, right? Who cares about educating hippos anyway?
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