It seems like the d-pad and face buttons, like those on the 3DS, are a little small and creaky. Analog sticks I'm not sure about. They could work, but they're pretty tiny. The game I played was an un-intriguing Little Deviants shooting gallery where you have to poke enemies, some from the front touch screen and others from the back.
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"God Hand is the ultimate expression of the joy of humanity, specifically the punching part of the joy of humanity."-Shigeru Miyamoto
Well... It was kind of hard to tell where the enemies were facing, and I did feel like I was shooting somewhat blindly, but you probably get used to what part of the back corresponds to what on the screen.