The MCU is now a deterministic hellscape where you can be melted if you make a "wrong" decision, where "wrong" is decided seemingly arbitrarily by three nebulous "beings".
Also, goodbye all of the drama of the entire rest of the MCU. Not only are the infinity stones apparently insignificant in the grand scheme of things, but everything was predetermined to go exactly as it did. Character decisions don't matter anymore, as if they make the "wrong" choice, they'll get melted.
Tony swallows his anger and doesn't attack Bucky at the end of Civil War? Melted.
Star-Lord pushes past his sorrow for the greater good and doesn't smack Thanos in the face on Titan? Melted.
What a catastrophic show.
Now let me note that I'm speaking purely from a worldbuilding perspective. The show aesthetically looks cool. The acting is fine, with some standout moments from Loki, e.g. watching the deaths of his parents and himself in the time theatre. It was neat to see Loki messing about in history as D.B. Cooper.
But that's all surface-level enjoyment. In terms of internal consistency, this is easily the worst MCU property yet.
Ya thats because we are about to have a multiverse that explains mutants and all that jumping into the MCU.