LogFAQs > #945221438

Vs Battles Wiki gives this as Sam's equipment:
Five-SeveN pistol, SC-20K M.A.W.S, SC knife, Multi-vision googles (allowing Sam three different modes of vision: Night-vision, Thermal vision and EM vision, plus the ability to switch between them instantly) Karambit "Panther's Claw" combat knife, Medikit, Ballistic shield, Binoculars, Alpha Ops suit, Tear gas, Sleeping gas, Sticky Shocker, Sticky EMP, Sticky cameras, noisemakers, Tactical audio kit, Stun gun, Taser, Crossbow, Incendiary grenades, EMP grenades, Smoke grenades, Phosphorous grenades, Proximity mines, Proximity shocker, Frag grenade, Breaching charges, Tri-Rotor retcon drone, Shotguns, Assault rifles, Sniper rifles, SMGs and the Spider-bot.

The Beast can likely handle anything Sam throws at him including grenades and proximity mines...at least at first. Those weapons would at least slow him down - you can see in the Lion's Roar video posted above that the Beast still lives after the attack (and IIRC he gets up and defeats them anyway) but he's weakened by it. I could see Sam tossing out some smoke grenades to confuse the Beast and follow it up with the Spider-Bot's machine gun fire. The Beast can catch one bullet, but can he catch or dodge rapidly fired bullets?

I doubt Sam opens with his strongest weapon. He doesn't strike me as the type to underestimate foes. He'd hide in the shadows and observe. The Beast looks like a frail old man, but Sam won't take any chances.

This is such an interesting match. If the Beast catches Sam, Sam is dead. But Sam might be able to pick away at the Beast's health with his weaponry. I wouldn't discount Sam here - he can use the terrain to his advantage far better than almost anyone in this contest.