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| Topic | Coronavirus 23: No Title |
| HiddenRoar 08/13/20 10:45:51 PM #68: | CobraGT posted... https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(20)30177-2/fulltext From your first link COVID-19 is generally a mild disease in children, including infants. However, a small proportion develop severe disease requiring ICU admission and prolonged ventilation, although fatal outcome is overall rare. Four patients, all older than 10 years, had a fatal outcome (CFR 069%, 95% CI 020182), with death occurring at 3, 9, 11, and 17 days after symptom onset. Two patients had no known pre-existing medical conditions; one had a cardiorespiratory arrest before arrival at the hospital and resuscitation was unsuccessful and the other died while being mechanically ventilated in ICU. The third patient had undergone human stem cell transplant 15 months earlier. The fourth patient was managed palliatively (without intubation), due to the severity of their pre-existing medical conditions. The remaining 578 patients were alive when the study closed. 93 (16%) individuals never developed clinical symptoms. In 460 (80%) individuals, all symptoms had resolved without apparent sequelae, whereas 25 (4%) were still symptomatic or were requiring respiratory support when the study closed. Nevertheless, our data indicate that children and adolescents are overall less severely affected by COVID-19 than adults, particularly older patients. Previous, large-scale data suggest that the CFR in adults older than 70 years is close to 10%, potentially due to immunosenescence. It is reassuring that our data show that severe COVID-19 is uncommon in young children, including infants, despite their immune maturation being incomplete,with only few requiring mechanical ventilation. It was striking that all children who died in our cohort were older than 10 years. ... Copied to Clipboard! |
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