The 3D isn't really 3D but something called Augmented reality which I think can actually affect your eyes after prolonged use IMO.
There is a game on PS3 called Eye of judgement that I played for hours on end and after about a month or two of constant use I started to have issues like extra sensitivity to light and whatnot. It even started to give me slight headaches frequently but maybe it has something to do with my eyes as I've reached the age of 30. I've always had perfect vision and never experienced any issues really till that game. Anyway to make a long story short I got rid of the game and have not had any similar issues since.
One big thing that I did notice though is that it became harder for me to focus on my collection of Magic Eye books which usually took moments for my eyes to adjust to.
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