Mortal Kombat (2011) has 7 female characters (Sonya, Kitana, Mileena, Jade, Sindel, Sheeva, and DLC character Skarlet). They talk about things other than men in Story Mode. For example, Kitana and Mileena talk about killing each other. Most fighting games fit the bill, really. Multiple female characters who talk to each other about how they will (or did) beat each other up.
Does the Portal series count? GLaDOS talks to Chell, but Chell is mute.
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Black Turtle spilled my diet soda!