Well, to be honest, for me, it feel Claymore is very much on the verge of ending. This current Arc should be ending pretty soon(Though with only 12 chapters per year it could go on for another 3 years...). They could always do one more arc, because it could always explore the other lands, but I think that's very unlikely.
I'm hopeful that Cassandra puts up a fight, along with the other AB's, but yeah, it's Priscilla. >_>