Dirk and Roxy being 400 years in the future explains many things. How they seem to have so much more technology (well, the lab excluded, since that was always there I guess), Roxy's and Dirk's hatred of Betty Crocker, and all those guys chasing Roxy in the lab.
Also, I'm a little disappointed they couldn't have had a better troll survive to the end instead of Kanaya. Like UU, she's also really boring compared to everyone else. Come to think of it, why is she a vampire again? I don't remember that ever being explained, but instead it just... happened.
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http://i50.tinypic.com/23qx00.jpg
"First time I got punched in the face, I was like "oh no", then I was like "this is a story"."