According to whom? One state?
If necessary, yes. The purpose of nullification is to fight against the tyranny of the majority, whether that majority is 26-on-24 or 49-on-1.
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SmartMuffin - Because anything less would be uncivilized - http://img.imgcake.com/smartmuffin/barkleyjpgde.jpg
http://dudewheresmyfreedom.com/