if VN's count, there are two big moments in Clannad that pretty much destroy anything else, and a bunch of other ones in stuff like G Senjou, Muvluv, Cross Channel, etc
if not, Valkyria Chronicles takes the cake for me
no other game has made me violently sob that hard
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"Duel audio? You mean like rap battles?" - termina_rzident
KrahenProphet and Kana are on opposite ends of the Awesome Spectrum.