Lurker > Antifar

ktownslayer16 posted...

whats the context? You work together? Blind date? Tinder?

Hinge. We only chatted for a couple messages about her work before she heavily hinted that I should ask her on a date, so I did.

ktownslayer16 posted...

Do you mean the fact shes in a wheelchair hasnt come up yet? Or to help her or not?

The fact that she's in a wheelchair.

CreekCo posted...

Theres something off about her eyes theres no light in em

I think it might be a filter to change her eye color

Autocraticus posted...

Is she getting dropped off/does she drive herself?

Well, it's NYC, so her transportation options are broader. The nearest subway stop is accessible, which isn't true of all of them.

_Krave_ posted...

Is she pretty?

Very much so

Eat_More_Beef posted...

Para? Quadra? I could see myself dating a paraplegic, but I think a quadra would be too much for me to handle.

It hasn't come up; we've exchanged like 5 messages total lol. From her photos, I'd say she has use of her arms.

neccis posted...

Don't dump her on the first date. Be a gentleman.

I mean, I wasn't planning on that

Now, that's not like, a deterrent to me, but it does kinda raise some questions about etiquette. It hasn't come up in our brief chat so far, is there an appropriate way to raise the subject? Do I...push her? It looks like a motorized chair from her photos.

ryudo500 posted...

do you ever think about a career change or something you really strongly wanted to do aside form your current job??

Yeah, I've decided I'm gonna learn to code and try and make a career off that.

No

I'm in a similar situation, where I have a very convenient office job that isn't rewarding in any real way, except in my case the alternatives are also things that I wouldn't care about, but would mean a bump in pay/benefits.

Imo: the convenient office jobs will still be around if you give coaching a go and decide it isn't for you.

It's easy to poke fun at this, but there is a lesson to be learned here for all of us about the folly of trying to change a hostile institution from within

Rarely in NYC, but there are no shortage of SUVs

g0ldie posted...

if you haven't seen it yet, you should also check out Dredd, starring Karl Urban.

I was asking the friends I watched with whether they'd seen Dredd, lol. Exactly what came to mind

That shit slapped

Smackems posted...

You act like he's the only one with an audience that just blindly accepts what he says, like he's the only one that broke through and found a way

He's far from the only one with an overzealous audience; his audience just happens to be one of the largest.

bigblu89 posted...

Men like to watch people dominate their sport.

Theres a reason why Serena Williams, even when unranked, gets some of the highest ratings in all of tennis, male or female. She dominates the sport.

Theres no female out there that can dominate her male counterpart in basketball.

This comparison doesn't work; Serena is every bit as overmatched by men as WNBA players.

Somewhere, a future school shooter finds his purpose.

Please help

Eugene V. Debs

Serious_Cat posted...

ITT: People who didn't read the article.

Yeah, there's nothing objectionable here

I4NRulez posted...

I mean idk why this is surprising. He said this the whole time and Harris was notoriously hard on crime in her career

It doesn't have to be surprising to be bad

runewalshPSiv posted...

Because people today have skin so thin that a strong breeze would rip them apart.

Is it thin skin, or that his jokes come at a time when GOP legislators across the country are pushing laws that would punish trans people for their existence?

Bump

https://gamefaqs.gamespot.com/a/user_image/8/2/1/AAWHm8AADfGd.jpg

https://twitter.com/JohnFetterman/status/1548034906277613570

brotrrwinner posted...

Ok but... why is a bakery organizing a drag show?

Because they wanted to, presumably.

https://twitter.com/DrRJKavanagh/status/1550705725596377088

It's fun to compare and contrast the posters here with those in discussions of Dave Chappelle

https://bit.ly/3zujRQ2

Last month, drug company Genentech reported on the first clinical trials of the drug crenezumab, a drug targeting amyloid proteins that form sticky plaques in the brains of Alzheimers disease patients. The drug had been particularly effective in animal models, and the trial results were eagerly awaited as one of the most promising treatments in years. It did not work. Crenezumab did not slow or prevent cognitive decline in people with a predisposition toward Alzheimers.

Last year, the Food and Drug Administration (FDA) narrowly approved the use of Aduhelm, a new drug from Biogen that the company has priced so highly that its expected to drive up the price of Medicare for everyone in America, even those who never need this drug. Aduhelm was the first drug to be approved that fights the accumulation of those "amyloid plaques" in the brain. What makes the approval of the $56,000-a-dose drug so controversial is that while it does decrease plaques, it doesnt actually slow Alzheimers. In fact, clinical trials were suspended in 2019 after the treatment showed no clinical benefits. (Which did not keep Biogen from seeking the drugs approval or pricing it astronomically.)

Over the last two decades, Alzheimers drugs have been notable mostly for having a 99% failure rate in human trials. Its not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimers has a record that makes the batting average in other areas look like Hall of Fame material.

And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimers research over the last 16 years might not just be wrong, but a deliberate fraud.

The suspicion that something was more than a little wrong with the model that is getting almost all Alzheimers research funding ($1.6 billion in the last year alone) began with a fight over the drug Simufilam. The drug was being pushed into trials by its manufacturer, Cassava Sciences, but a group of scientists who reviewed the drug makers claims about Simufilam believed that it was exaggerating the potential. So they did what any reasonable person would do: They purchased short sell positions in Cassava Sciences stock, filed a letter with the FDA calling for a review before allowing the drug to go to trial, and hired an investigator to provide some support for this position.

As Science reports, it was that investigator, Vanderbilt University neuroscientist and junior professor Matthew Schrag, who tipped over the whole applecart to discover that it wasnt just that Cassavas drug was ineffective. Theres good evidence that for the last 16 years, almost everyone has had the wrong idea about the cause of Alzheimers. Because of a fraud.

In 2006, Nature published a paper titled A specific amyloid- protein assembly in the brain impairs memory. Using a series of studies in mice, the paper concluded that memory deficits in middle-aged mice were directed caused by accumulations of a soluble substance called A*56. This was a specific form of a group known as toxic oligomers that had long been suspected as the possible precursors of amyloid plaques. The paper then went on to directly connect that condition to cognitive deficits associated with Alzheimer's disease independently of other conditions affecting the aging brain.

The study didnt come out of nowhere; it only seemed to confirm one of several hypothesis about Alzheimers that had been circulating for many years by that point. After all, the brains of Alzheimers patients do contain plaques that can sometimes seriously alter the structure of the brain. Those plaques do contain amyloids. Its not much of a stretch to suggest those amyloids are a primary cause of the associated memory loss and dementia. Amyloids cause plaques, plaques cause damage, the damage causes Alzheimer's. QED.
...
What intrigued Schrag when he came back to this seminal work were the images. Images in the paper that were supposed to show the relationship between memory issues and the presence of A*56 appeared to have been altered. Some of them appeared to have been pieced together from multiple images. Schrag shied away from actually accusing this foundational paper of being a fraud, but he definitely raised red flags. He raised those concerns, discreetly at first, in a letter sent directly to the National Institutes of Health (NIH). Only when that letter failed to generate a response did Schrag bring his suspicions to others.

Now Science has concluded its own six-month review, during which it consulted with image experts. What they found seems to confirm Schrags suspicions.

They concurred with his overall conclusions, which cast doubt on hundreds of images, including more than 70 in Lesns papers. Some look like shockingly blatant examples of image tampering, says Donna Wilcock, an Alzheimers expert at the University of Kentucky.

After reviewing the images, molecular biologist Elisabeth Bik said of the paper, The obtained experimental results might not have been the desired results, and that data might have been changed to better fit a hypothesis.

Should this fraud turn out to be as extensive as it appears at first glance, the implications go well beyond just misdirecting tens of billions in funding and millions of hours of research over the last two decades. Since that 2006 publication, the presence or absence of this specific amyloid has often been treated as diagnostic of Alzheimers. Meaning that patients who did die from Alzheimer's may have been misdiagnosed as having something else. Those whose dementia came from other causes may have falsely been dragged under the Alzheimers umbrella. And every possible kind of study, whether it's as exotic as light therapy or long-running as nuns doing crossword puzzles, may have ultimately had results that were measured against a false yardstick.

tl;dr: the study "showing" what causes alzheimers appears to have used heavily doctored images to support its hypothesis.

https://www.reuters.com/world/us/exclusive-hyundai-subsidiary-has-used-child-labor-alabama-factory-2022-07-22/

A subsidiary of Hyundai Motor Co has used child labor at a plant that supplies parts for the Korean carmaker's assembly line in nearby Montgomery, Alabama, according to area police, the family of three underage workers, and eight former and current employees of the factory.

Underage workers, in some cases as young as 12, have recently worked at a metal stamping plant operated by SMART Alabama LLC, these people said. SMART, listed by Hyundai in corporate filings as a majority-owned unit, supplies parts for some of the most popular cars and SUVs built by the automaker in Montgomery, its flagship U.S. assembly plant.

Hyundai (005380.KS) didn't respond to phone calls or emails from Reuters seeking comment.

SMART, in a statement, said it follows federal, state and local laws and "denies any allegation that it knowingly employed anyone who is ineligible for employment." The company said it relies on temporary work agencies to fill jobs and expects "these agencies to follow the law in recruiting, hiring, and placing workers on its premises."

SMART didn't answer specific questions about the workers cited in this story or on-the-job scenes they and other people familiar with the factory described.

Reuters learned of underage workers at the Hyundai-owned supplier following the brief disappearance in February of a Guatemalan migrant child from her family's home in Alabama.

The girl, who turns 14 this month, and her two brothers, aged 12 and 15, all worked at the plant earlier this year and weren't going to school, according to people familiar with their employment. Their father, Pedro Tzi, confirmed these people's account in an interview with Reuters.

Police in the Tzi family's adopted hometown of Enterprise also told Reuters that the girl and her siblings had worked at SMART. The police, who helped locate the missing girl, at the time of their search identified her by name in a public alert.

Reuters is not using her name in this article because she is a minor.

The police force in Enterprise, about 45 miles from the plant in Luverne, doesn't have jurisdiction to investigate possible labor-law violations at the factory. Instead, the force notified the state attorney general's office after the incident, James Sanders, an Enterprise police detective, told Reuters.

Mike Lewis, a spokesperson at the Alabama attorney general's office, declined to comment. It's unclear whether the office or other investigators have contacted SMART or Hyundai about possible violations.

I like this better when the pineapple guy does it

I'd have gotten so many chances back in high school

https://twitter.com/timmarchman/status/1550270084811210753

https://twitter.com/atrupar/status/1550145770283827200

https://twitter.com/HeartlandSignal/status/1550144016972496897

Wait, they updated it this far out from release? I might have to check that out

Like a lot of Trump secrets that have been "revealed" after the fact, it was obvious at the time to those who could add 2+2, but the media treats motivations as unknowable unless someone writes in an email "I would like to maximize our power at the expense of others."

mustachedmystic posted...

Remember AOC and her green new deal(or whatever it was called)? People all over the political spectrum ripped it, and her to shreds.

We can change the politics, or we can change the science. Which do you think is more likely?

https://www.vice.com/en/article/epzxba/indiana-mall-gunman-4chan

Hours before a 20-year-old gunman opened fire on a food court in a suburban mall near Indianapolis on Sunday, he appears to have posted a grim message on the notorious imageboard site 4chan.

Name is jonathan and today seems like a good day to die, he wrote. The post was accompanied by a colorized image of a wedding in Nazi Germany. He also shared a link to the image-hosting site Imgur, which contained several images of himself wearing a white button-down shirt, blue jeans, a face-covering, and posing with two AR-15-style rifles, a handgun, and multiple magazines.

That post was shared on July 17 at 1:13 p.m. (the site lists no time zone) to the websites /BANT boardwhich is its International/Random board. Just before 6 p.m. local time the gunman, identified as Jonathan Sapirman, walked out of the Greenwood Park Malls food court restrooms armed with the same type and number of weapons as seen in the photo and began shooting into the crowd with an assault rifle (specifically, a Sig Sauer model M400 5.56). He killed three people and injured two more. Less than 30 seconds after his rampage began, a civilian shot him dead from over 40 yards away with a handgun.

Police have not yet identified any clear motive in the attack. At a press conference Monday, they said the shooter had left his laptop in a heated oven, alongside a can of butane, and submerged his cellphone in the toilet. Police did not speculate on the reasons the shooter did this but said investigators were trying to acquire as much information from the damaged devices as they could. The FBI took the damaged laptop to their lab in Quantico for further analysis. Police told VICE News that they were familiar with the comments and images purportedly posted by the gunman prior to the attack.

Meanwhile, an apparently leaked image from the crime scene has further complicated matters.
VICE News asked Greenwood Police about a sensitive, graphic photo, apparently taken inside the mall, and uploaded to 4chan on Tuesday. The picture purports to show the deceased gunman lying on the floor of the mall alongside a placard identifying him as dead. The police chief did not dispute the images authenticity, and said that they were investigating where it came from. The dead body is wearing the same clothes as the person who posted on 4chan linking to the Imgur album.

Evidence of the shooters presence on 4chan first began circulating online Monday, raising questions about his motive. The infamous anonymous imageboard site has been linked to a slew of ideologically motivated killings in recent years. The imageboard site was a primary source of radicalization for the 18-year-old who killed 10 people in a racist attack on a Buffalo supermarket earlier this year, according to the vitriolic screed hed posted online prior to the shooting.

The man who killed 51 people in an attack on two mosques in Christchurch, New Zealand, in 2019 also said that he frequented 4chan. The man who killed 10 people in a misogyny-inspired Toronto van attack said he frequented the site as well. In the weeks before the Jan. 6 Capitol riot, 4chan was awash with violent rhetoric and threats against lawmakers, Congressional investigators said at a recent hearing.

mustachedmystic posted...

youre really gonna complain that Liberals arent doing enough when Conservatives want to burn more coal?

Big gap between "better than conservatives" and "in line with what scientists say is necessary to prevent catastrophic impacts from climate change."

Damn, these guys don't seem particularly concerned with the consistency of their arguments

Enjoy the 5,000 seat arena the Coyotes are playing in next year

pogo_rabid posted...

Wait why are they dumping road america?

It's only 150 miles from Chicago; they feel there's no need for two summer races in that area

kelemvor posted...

Even if they meet republicans in the middle and say every state has to allow abortion in the 1st or 2nd trimester. ( That would probably be 99% of all abortions)

Republicans would not meet there.

Now, there's a good case for putting forth bills to protect abortion in cases of rape/incest, life of the mother, etc. You'll either peel off enough Republicans or get them on the record voting against popular provisions.

This is something that Democrats can and should be doing; it's a hugely popular issue and a massive source for concern for their base, and they are likely to be able to pass it.

https://gamefaqs.gamespot.com/a/user_image/4/8/6/AAWHm8AADeSW.jpg
Here's what the circuit looks like

It's neat! You can just build full on Hot Wheels tracks! And it's very hard to keep your car on those tracks, lol.

Both would be decent pay/benefit increases over my current job (one more decent than the other). But they're lateral moves career wise and my fear is they'll leave me with less time to build skills for something more. Like if I want to learn to code, my current job has a lot of downtime that would enable that...but then these jobs would mean less time in the office overall, so maybe that's a wash.

/blogFAQs