I know you said it doesn't have to be sitcom moms, but I can't really think of any good non-sitcom choices off the top of my head.
Id put that in firm exclusive tier 1.1 with Clayfighter 63 1/3 and Fighter's History
Games that I think are worth considering for this rushmore
Street Fighter 2
Street Fighter 4
Mortal Kombat
Mortal Kombat 2
Tekken
Tekken 3
Soul Calibur 2
X-Men vs Street Fighter
Marvel vs Capcom 2
Marvel vs Capcom 3
King of Fighters 94
King of Fighters 98
Super Smash Bros Melee
Super Smash Bros Ultimate
Don't think any others really should be in the discussion
Street Fighter 2
Mortal Kombat
Tekken
King of Fighters '94
Darth VaderChange Thanos to Terminator, sorry I should've read the rules closer.
Freddy Krueger
Keyser Soze
Thanos
Cottonmouth