Current Events > How are anti depressants supposed to work

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TheGoldenEel
01/30/18 7:57:08 PM
#1:


They do make it easier to put the mask on but I still hate being alone with my own thoughts

Is this normal or should I go back to my doctor
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3deep5u
01/30/18 7:58:22 PM
#2:


They promote regeneration of neurons in your white matter.

so does marijuana
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TheGoldenEel
01/30/18 7:59:17 PM
#3:


3deep5u posted...
They promote regeneration of neurons in your white matter.

so does marijuana

Marijuana amps my self consciousness up to 11, I dont like it
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3deep5u
01/30/18 7:59:34 PM
#4:


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Pepys Monster
01/30/18 8:00:27 PM
#5:


For me, they didn't work.
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TheGoldenEel
01/30/18 8:01:56 PM
#6:


3deep5u posted...
https://www.scientificamerican.com/article/unraveling-the-mystery-of-ssris-depression/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543605/

I dont mean how, scientifically, do they work.

I mean how am i supposed to feel
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chill02
01/30/18 8:02:20 PM
#7:


how long have you been taking them
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Coffeebeanz
01/30/18 8:02:39 PM
#8:


SSRIs are still up for debate, but Wellbutrin works by increasing the amount of norepinephrine and dopamine in the central nervous system, which promotes alertness and a sensation of being rewarded for what you're doing.
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weapon_d00d816
01/30/18 8:02:42 PM
#9:


They give you more serotonin, so in other words they literally just force you into a good mood.
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Pepys Monster
01/30/18 8:02:54 PM
#10:


TheGoldenEel posted...
3deep5u posted...
https://www.scientificamerican.com/article/unraveling-the-mystery-of-ssris-depression/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543605/

I dont mean how, scientifically, do they work.

I mean how am i supposed to feel

I don't know, I still felt depressed.
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Coffeebeanz
01/30/18 8:04:14 PM
#11:


TheGoldenEel posted...
3deep5u posted...
https://www.scientificamerican.com/article/unraveling-the-mystery-of-ssris-depression/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543605/

I dont mean how, scientifically, do they work.

I mean how am i supposed to feel


It depends on the antidepressant

Fluoxetine - Alert, energetic, but somewhat apathetic

Paroxetine - Calm, relaxed, sometimes tired

Bupropion - Focused, alert, somewhat anxious

Sertraline - Halfway between fluoxetine and paroxetine
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TheGoldenEel
01/30/18 8:05:03 PM
#12:


chill02 posted...
how long have you been taking them

Since September
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Sami1000
01/30/18 8:06:15 PM
#13:


If you hate feeling stuff, they're good. Makes you more mentally numb and possibly more passive and anemic because you're less interested in anything.

At least for me, thry have done just that. I have eaten 4-5 kinds for over ten years, and if i could go back in time i wouldn't start taking them. At this point they have likely done only damage, and zero helping.
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TheGoldenEel
01/30/18 8:06:57 PM
#14:


Yeah Im taking fluoxetine and it makes me want to do things more than usual but also when Im out doing those things I feel like no one will ever love me and Im wasting my time
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#15
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MedeaLysistrata
01/30/18 8:08:06 PM
#16:


sometimes the person taking them doesn't feel any different, but the people around that person notice the changes.
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Coffeebeanz
01/30/18 8:08:53 PM
#17:


TheGoldenEel posted...
Yeah Im taking fluoxetine and it makes me want to do things more than usual but also when Im out doing those things I feel like no one will ever love me and Im wasting my time


You'd probably do better with Bupropion (Wellbutrin).

It has the stimulating properties of fluoxetine but instead of blunting emotions, it tends to amp them up a bit. Bupropion is actually a distant cousin to the amphetamines, but without the addictiveness or high.
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COVxy
01/30/18 8:12:40 PM
#18:


3deep5u posted...
They promote regeneration of neurons in your white matter.

so does marijuana


This isn't an accurate statement lol
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3deep5u
01/30/18 8:13:18 PM
#19:


COVxy posted...
3deep5u posted...
They promote regeneration of neurons in your white matter.

so does marijuana


This isn't an accurate statement lol

Read the sources I posted.

Feel free to correct me too.
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Coffeebeanz
01/30/18 8:14:24 PM
#20:


Also, just a word of advice - don't ever get psychiatric med advice from people who aren't psychiatrists or at least medical professionals. The most common mistake people make is using the medication incorrectly and then telling everyone else how bad it was.
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3deep5u
01/30/18 8:15:04 PM
#21:


Coffeebeanz posted...
Also, just a word of advice - don't ever get psychiatric med advice from people who aren't psychiatrists or at least medical professionals. The most common mistake people make is using the medication incorrectly and then telling everyone else how bad it was.

I got mine from a nurse practitioner, not a psychiatrist.
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COVxy
01/30/18 8:15:46 PM
#22:


3deep5u posted...
Read the sources I posted.

Feel free to correct me too.


Well, I mean, there are no neurons in white matter, as white matter is consistent of the axons extending from cell bodies. Cell bodies are grey matter.

The idea of SSRIs promoting synaptogenesis isn't wrong, you are just using the wrong jargon.
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3deep5u
01/30/18 8:16:28 PM
#23:


Okay, thank you for clarifying.
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PhlogPyro
01/30/18 8:17:50 PM
#24:


well in my experience, they fucking don't
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weapon_d00d816
01/30/18 8:25:01 PM
#25:


Coffeebeanz posted...
SSRIs are still up for debate, but Wellbutrin works by increasing the amount of norepinephrine and dopamine in the central nervous system, which promotes alertness and a sensation of being rewarded for what you're doing.

Wellbutrin is glorified caffeine.

Vyvanse instantly kicked my depression. Like literally instantly. It stopped and never came back from the moment the first dose kicked in. But yeah, it's an amphetamine, and it's hard to justify going on it if you don't have ADHD.
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COVxy
01/30/18 8:25:22 PM
#26:


3deep5u posted...
Okay, thank you for clarifying.


Also, needless to really say, it's not accurate to say marijuana does the same thing. My guess is that you are just looking for justifications for your self imposed cessation of SSRIs and self medication via marijuana.
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Coffeebeanz
01/30/18 8:25:42 PM
#27:


weapon_d00d816 posted...
Coffeebeanz posted...
SSRIs are still up for debate, but Wellbutrin works by increasing the amount of norepinephrine and dopamine in the central nervous system, which promotes alertness and a sensation of being rewarded for what you're doing.

Wellbutrin is glorified caffeine.

Vyvanse instantly kicked my depression. Like literally instantly. It stopped and never came back from the moment the first dose kicked in. But yeah, it's an amphetamine, and it's hard to justify going on it if you don't have ADHD.


Vyvanse is literally amphetamine. Literally. Just not appropriate for most people.
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weapon_d00d816
01/30/18 8:28:01 PM
#28:


Coffeebeanz posted...
weapon_d00d816 posted...
Coffeebeanz posted...
SSRIs are still up for debate, but Wellbutrin works by increasing the amount of norepinephrine and dopamine in the central nervous system, which promotes alertness and a sensation of being rewarded for what you're doing.

Wellbutrin is glorified caffeine.

Vyvanse instantly kicked my depression. Like literally instantly. It stopped and never came back from the moment the first dose kicked in. But yeah, it's an amphetamine, and it's hard to justify going on it if you don't have ADHD.


Vyvanse is literally amphetamine. Literally. Just not appropriate for most people.

If my patient was suicidal and I was a psychiatrist I would highly consider it.
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3deep5u
01/30/18 8:28:36 PM
#29:


COVxy posted...
My guess is that you are just looking for justifications for your self imposed cessation of SSRIs and self medication via marijuana.

Read the sources I posted and look it up for yourself. I might be remembering it wrong. I'm on the phone too.

http://lmgtfy.com/?q=marijuana+neurogenesis

Using this because google links suck
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Sami1000
01/30/18 8:29:52 PM
#30:


Coffeebeanz posted...
Also, just a word of advice - don't ever get psychiatric med advice from people who aren't psychiatrists or at least medical professionals. The most common mistake people make is using the medication incorrectly and then telling everyone else how bad it was.


Yeah, i agree. Never trust a person who has eaten said meds for years or decades. Trust some corporate shills, who read information from the back of the box.
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COVxy
01/30/18 8:30:37 PM
#31:


Neurogenesis and synaptogenesis are two very different processes, and the primary results in SSRI research seem to point to synaptogensis. Plus the marijuana effects on neurogenesis are very complicated, dose dependent, and never related to depressive symptoms.
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3deep5u
01/30/18 8:31:19 PM
#32:


Where does the neurogenesis take place?
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AmonAmarth
01/30/18 8:32:05 PM
#33:


ive heard doctors themselves dont know the exact way.

but i kinda relates to neurotransmitters, serotonin or others,
and a few other things.
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COVxy
01/30/18 8:33:06 PM
#34:


3deep5u posted...
Where does the neurogenesis take place?


Primarily, research on adult neurogenesis focuses on the dentate gyrus of the hippocampus, but I think along the lining of the ventricles has been shown as well. These are very localized effects, unlike synaptogensis, which is a brain wide phenomenon.
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AmonAmarth
01/30/18 8:36:24 PM
#35:


Sami1000 posted...
Coffeebeanz posted...
Also, just a word of advice - don't ever get psychiatric med advice from people who aren't psychiatrists or at least medical professionals. The most common mistake people make is using the medication incorrectly and then telling everyone else how bad it was.


Yeah, i agree. Never trust a person who has eaten said meds for years or decades. Trust some corporate shills, who read information from the back of the box.


lol. kinda true. many mds so often just ignore the side effects or arent aware of them. they dont understand the actual feelings or "being in touch" with the patient.

for example some of the sexual side effects. pssd (they be like wats that), or the fact that many ssris basically make you close to sterilized (maybe im using the wrong word but they go beyond just reducing libido) while talking them.
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3deep5u
01/30/18 8:37:18 PM
#36:


I got my wife pregnant while on 150 mg of Effexor
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Coffeebeanz
01/30/18 8:37:37 PM
#37:


Sami1000 posted...
Coffeebeanz posted...
Also, just a word of advice - don't ever get psychiatric med advice from people who aren't psychiatrists or at least medical professionals. The most common mistake people make is using the medication incorrectly and then telling everyone else how bad it was.


Yeah, i agree. Never trust a person who has eaten said meds for years or decades. Trust some corporate shills, who read information from the back of the box.


All I can say is this - you don't realize how little you know about something until you try to learn about it.

Well, that and people who say they "eat" medications are kinda weird
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Coffeebeanz
01/30/18 8:39:02 PM
#38:


Oh goodness, here come the psych peeps with their sage advice. Sorry, TC, I'm out. There are some battles not worth fighting.
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AmonAmarth
01/30/18 8:40:51 PM
#39:


this study is "nice":

Safarinejad (2008) examined 74 fertile, depressed men who had been taking a variety of SSRIs (citalopram, escitalopram, fluoxetine, paroxetine, or sertraline) for at least six months. Compared to control group of 44 healthy fertile men, those taking SSRIs had significantly lower sperm counts, significantly lower sperm motility, lower sperm density, higher DNA fragmentation, and poorer sperm morphology (i.e., more
defective in terms of size and shape). Safarinejad found that the longer a man had been taking an SSRI, the more abnormal his semen parameters. Additionally, Safarinejad found that no one SSRI appeared to be more detrimental to semen parameters than
another. Another research group (Tanrikut et al., 2010) examined only paroxetines effect on sperm. In their sample of 35 healthy male volunteers, exposure to paroxetine over the course of five weeks had marked effects on their sperms DNA integrity. While other parameters (count, motility, morphology) remained within normal limits, significant increases in DNA fragmentation were noted (13.8% to 30.3%). This is important to note
given 30% is generally considered the threshold for infertility. The percentage of men with 30% or greater DNA fragmentation rose from 9.7% to 50% over the course of the five week study. Also reported by their subjects was worsened erectile function (35%) and ejaculatory function (47%)


keeping popping those pills kids,mds especially in the US are overprescripting these pills to the point of insanity.
men or woman comes with the big black business suitcase. hey md heres what he have to offer.
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3deep5u
01/30/18 8:41:31 PM
#40:


^That's why I quit tbh
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AmonAmarth
01/30/18 8:45:43 PM
#41:


a couple decades ago they said ssris cause 25% sexual libido, and related problems, then 50 percent
now the numbers are at 70-90 (with clomipramine having 90%) rates of messing with you.
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Coffeebeanz
01/30/18 8:46:11 PM
#42:


men or woman comes with the big black business suitcase. hey md heres what he have to offer.

I haven't prescribed a name-brand antidepressant in... well, ever.

All the SSRIs and most of the SNRIs are generic. So the only black suitcases I see are ones I'm currently smashing my head on after reading your asinine comments.
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Coffeebeanz
01/30/18 8:47:33 PM
#43:


AmonAmarth posted...
a couple decades ago they said ssris cause 25% sexual libido, and related problems, then 50 percent
now the numbers are at 70-90 (with clomipramine having 90%) rates of messing with you.


Clomipramine is a tricyclic, not an SSRI, and it's not even prescribed for standard depression.
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chill02
01/30/18 8:47:35 PM
#44:


I'd be fucked without sertraline
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Deadpool_18
01/30/18 8:48:03 PM
#45:


They keep me from doing the worst, so yeah, they work like hell.
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AmonAmarth
01/30/18 8:48:37 PM
#46:


Coffeebeanz posted...
men or woman comes with the big black business suitcase. hey md heres what he have to offer.

I haven't prescribed a name-brand antidepressant in... well, ever.

All the SSRIs and most of the SNRIs are generic. So the only black suitcases I see are ones I'm currently smashing my head on after reading your asinine comments.


you is one person. how about the thousands and thousands? who DO overprescribe.
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Deadpool_18
01/30/18 8:49:04 PM
#47:


chill02 posted...
I'd be fucked without sertraline


I take a cocktail of Lexapro and Wellbutrin because my doctor says I have one of the most overactive brains and horrible depression that he has ever seen. I wouldnt know. I just know that it helps me enjoy things.
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AmonAmarth
01/30/18 8:49:04 PM
#48:


Coffeebeanz posted...
AmonAmarth posted...
a couple decades ago they said ssris cause 25% sexual libido, and related problems, then 50 percent
now the numbers are at 70-90 (with clomipramine having 90%) rates of messing with you.


Clomipramine is a tricyclic, not an SSRI, and it's not even prescribed for standard depression.


well aware of that. the point is that the numbers have gone up, even with SSRIs.
plus ssris, snris and tricylics are given for tons of anxiety cases, its not just depression.
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Coffeebeanz
01/30/18 8:51:43 PM
#49:


SNRIs aren't usually prescribed for anxiety considering their mechanism of action is to increase the neurotransmitter that causes anxiety (norepinephrine)

Honestly, I don't think I've used duloxetine for anything other than neuropathic pain
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AmonAmarth
01/30/18 8:55:18 PM
#50:


Coffeebeanz posted...
SNRIs aren't usually prescribed for anxiety considering their mechanism of action is to increase the neurotransmitter that causes anxiety (norepinephrine)

Honestly, I don't think I've used duloxetine for anything other than neuropathic pain


perhaps. i think effexor and cymbalta were some of the ones I tried (to augementation).
but ive taken dozens of meds over my life time, and aside from helping panic disorder,
did nothing for ocd, social phobia, and minimimal help for depression. (yep im just one person).
regardless of dosage or time period.. so im not happy with them.

i realize the meds help some people, but i still think too much given too easily to people in some areas.
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