You'd need to either have someone playing each one, or a mod to give some players DM powers, so they can move NPCs manually.
And a die-rolling mod.
In fact, you'd need to mod the hell out of it for it to be of much use, but it would still be a fantastically awesome set of mods to have, and I very much encourage anyone who wants to have a crack at it to make it happen.
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"I'm Commander Shepard, and you're standing in the biggest library in Citadel Space. Look me up."