I actually decided to play the game because you posted music in a random topic recently and it sounded neat. I've had the Signalis icon on my desktop for a while now, and that was the final push I needed.
More thoughts.
I think the biggest thing I'm still wrapping my head around is location. For most of the last 1/3 of the game, I thought Ariane had crash-landed near the mines somehow. Turns out she just went flying out into space for HUNDREDS OF YEARS, and is still out there. Falke discovering the red gate below the mines was technically a different incident. Apparently Ariane was such a strong bioresonant that she reached them across the universe.
Although that ties nicely into the themes of their oppessive/repressive society. Bioresonance is the backbone of their civilization, and some people up top are even worried about what will happen when the few people capable of bioresonance die out. But they stifle Ariane at every turn, to the point where she can't explore her own interests, to the point where the only person who ever figures out she's bioresonant is an enemy spy. If they had allowed her to flourish, they could have had a new supreme leader to lead them into a golden age.
Instead she fucks off to deep space, gets cancer, gets put in cryosleep, and turns reality into meat moss. Whoops.