The opening sequence is striking. Depression or a similar mental illness can certainly feel apocalyptic at times, so I like the metaphor, and cosmic sci-fi is just a cool backdrop for the main story.
Justine's wedding is nightmarish, not just because it's painfully awkward, but also from the passage of time and everyone's behavior seeming slightly off. Everything that can go wrong between Justine and those close to her does, and one could imagine having this kind of irrational fear before a big life event like this.
Overall it captures feelings of sadness and despondency very well, while making our personal troubles seem insignificant, because after all, a giant death planet could come along and smash us up any day now.
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azuarc wasn't even home. he was playing Magic the Gathering at his buddy's store, which is extremely easy to verify