Golden Sun 53.69% 30920 Grand Theft Auto: San Andreas 46.31% 26674 TOTAL VOTES 57594
This one wasn't unthinkable, but it was still super satisfying. GTA already had a history of.. let's call them questionable results, starting with CJ losing to Ness in 2005, but those were character battles. Vice City put up a serious result on Melee back in 04 and Vice City beat Metroid Prime in a weird 09 match. San Andreas came in last in 09, but it was a really tight poll of midcarders where no one got more than 27%.
Meanwhile, Golden Sun is a GBA game for babies. Its most memorable performance was some dude named Felix pulling 47% on Master Chief -- a clue for how this match might go with favourable circumstances. Round 1 came and Golden Sun put up a higher percentage on Ratchet & Clank than San Andreas did on Dead Space. At that point, the writing was on the wall, but it was still a GBA game vs. one of the biggest games of the decade, if not all time.
This match ended up not really being that close, but it still felt great to get right.