Advertisers burned the bridge and pissed on the ashes. Ads getting louder, more intrusive and frequent was an asshole move that just hurt them. Packing them full of malware just made it so you're forced to block them for security reasons.
They made this situation, so fuck them. Ublock and Noscript are always on for me, and that's not changing.
This isn't hurting advertisers, though - advertisers don't pay for ads you don't see. Ad-block doesn't honestly make much of a difference for them, because they only have to pay out for ads that successfully load (or ads that are viewed all the way through or clicked in the case of video ads).
Who it does make suffer is the content providers, since you've taken away their main source of income. If you are using an ad-blocker, then unless you're supporting the site some other way (you're providing content to the site, donating via Patreon, etc.), you don't really have a right to be using it anymore. I do think it's a bit selfish that people get on their high horse and say "I only block because the ads are invasive/really annoying/etc.", yet still feel they have a right to use a service they're now not even paying for.
If you want to hurt advertisers rather than content-providers, click on their ads then immediately close out of the resultant site. They have to pay the host, but you aren't buying anything.
That's just too bad, isn't it? I will never, ever allow, or click on ads because I'm not risking malware problems. Stop being a fucking shill, it's pathetic. I don't owe anybody anything, because I do what benefits me - just like every single asshole advertiser that tries to disrupt people for their own pay. If you want capitalism, you get it both ways. ---
I have a signature. Apparently this is important, but I still don't have my secret cool kid decoder ring yet.