Revered in comedy circles, Rickles also had dramatic chops.
In 1995 he portrayed the trusted floor boss in Scorsese's gangster drama "Casino."
In 2014, the legendary director joined "Casino" star Robert De Niro in roasting Rickles during Spike TV's "One Night Only: An All-Star Comedy Tribute to Don Rickles."
"Bob and I did like eight pictures together," Scorsese joked. "Then we did 'Casino' with Don, 20 years ago -- and we haven't worked together since."
A whole new generation fell in love with Rickles' work after he was cast as the voice of "Mr. Potato Head" in the "Toy Story" films.
In February Rickles told Closer Weekly he had no plans to retire despite his advanced age.
He said he was still operating with the same spontaneous humor he always had.
"I don't practice or write stuff down -- everything I do onstage was just made up before I went on," he said.
"You can't please everyone, but I've been fortunate in that my fans are in my corner."
Rickles added that he was grateful for his continued audience after so many years in the business.
"Whether it's 10 people or 300 people, an audience is still an audience," he said. "If people keep showing up to see you, then it's still a high."