I was gonna say you can play Radiant Dawn without playing Path of Radiance. I never played the latter and I absolutely love Radiant Dawn. It's the only Wii game I love in fact.
Otherwise I vote for Mass Effect, and then play 2.
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~Halo There is no Crane, only Scarecrow!
http://img195.imageshack.us/img195/3739/scarecrowq.jpg