Link vs. Ganondorf
Mega Man vs. Dr. Wily
Link/Ganon hasn't been challenged yet. Next round, though!
Alucard vs. Dracula
Frog vs. Magus
Another terribly tough pick. Both of these are among my favorites, but Frog/Magus edges out the vamps. Dat ending...
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Yoblazer: http://i44.tinypic.com/5nw45i.jpg
Watch and you'll see... someday I'll be... part of your world!