From: PerfectChaosZ | #006
I knew it was a Prequel, but I considered that maybe that means I wouldn't have had to play any of the games since the story-lines of those hadn't happened and wouldn't be relevant. XD
...what? By saying "Reach is a prequel" I'm saying "You don't need to have played the others." It does lead directly into the first game and has kinda-spoilers for the main trilogy, but nothing you wouldn't expect.
Staying away from fighting games, there's also Borderlands, Left 4 Dead 1 and 2, Call of Duty 4, Portal 2, Resident Evil 5 (though I will say, the splitscreen on this is ridiculous), and on the downloadable front Sonic the Hedgehog 2, TMNT Turtles in Time, Doritos Crash Course (bonus: It's free), Scott Pilgrim vs. the World, Perfect Dark, and Rainbow Six Vegas 2.
Sticking to games I've played locally myself, that is, I'm sure there's much more.
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JonthePenguin
http://www.backloggery.com/main.php?user=erunion