LogFAQs > #961407739

Small damage reduction.
Change the equip load thresholds, let them have the fast roll (more frames on it too if you want) at higher equip loads. Or just cut equipment weight.
Humanity now provides regen for a while after the full heal.
Worse drop rates

RE4-esque removed areas:
Open the big gate in Anor Londo from the start, forget the side route.
Gwyndolin is hard mode only.
Painted world is open if you approach the painting without the item, but completely deserted.
O&S are fought one after another, engage one and the other goes back up an elevator until his turn.
Big ladder down the catacombs.
Tomb of the giants has another slide that skips the lower part with the quadrupeds and the knight.
Run into the hole now covered in signs and indications at the start of Chasm of the Abyss to fight Manus instead of playing the level.
Kalameet is hard mode only and does not appear earlier in Royal Wood.
As you first enter Gwyn's room he is so startled that he accidentally lights himself on fire and loses 2/3 of his health.