I mean I could see Mass Effect 4 basically being the survivors of the Normandy hunting for Shepard, which can only work if Destroy is canon.
Maybe though my guess for the time could be either not so long after or WAAAAY after (like hundreds of years). They make a point to show the Andromeda galaxy in the starting bit and the radio chatter mentions "initiate first contact protocols". Maybe the colored light show of choice at the end of ME3 attracted the Remnant from Andromeda or some other out galactic thing and they are coming to say hi. They could also do something with the Leviathans. Those are still a thing
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XBL GT: Demon Ninja X2 "There comes a time in every man's or woman's life where they have to make **** up to cover their ass." - Hazama