LogFAQs > #910957750

Yes, sometimes. There are many different variants of the influenza virus as it mutates rapidly, so every year the CDC and other organizations try to predict which strands will be the most widespread or significant and creates a cocktail vaccination to cover them in an attempt to prevent their spread as much as possible. If you get a flu shot, it will protect you (and more importantly everybody else) from those strands, but it's not a guarantee that you won't catch a different variant of the flu.

For something that's usually free and takes very little time, it's absolutely worth it.
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Irregardless, for all intensive purposes, I could care less.