LogFAQs > #906720158

Should be solid, can't really go wrong with that.

I'd highly recommend the Comprehension perk at level 4, so you can get the most out of both skill books and skill magazines (the former give small yet permanent boosts while the latter give large but short-lived boosts).

As you go through the game, make a point of collecting Mentats, Honey Mesquite (large yellow-green plants), and Whiskey. With a Science skill of 50, these can be mixed at a campfire into Party Time Mentats, which are excellent for temporarily boosting CHA. Additionally, hang on to Moonshine - its the only liquor that can stack boost on top of other liquors. After you get the CHA implant, keep some Party Time Mentats, some Moonshine, and any other liquor in your inventory at all times, and you can boost your CHA from a base of 2 all the way up to 10 whenever the need arises.

Furthermore, as soon as you get to Freeside (Vegas outskirts), buy the Naughty Nightwear from Mick and Ralph's, which gives +1 LCK and +10 Speech; hugely helpful for casinos and speech checks. Pair all of this with a Comprehension-boosted Meeting People magazine and you can pass speech checks of 80 with a mere 2 base CHA and 34 base Speech.

Tl;dr Party Time Mentats = Mentats, Whiskey, Honey Mesquite. Keep Moonshine and another liquor on hand. Buy Naughty Nightwear from Mick and Ralph's in Freeside. Pass the vast majority of the game's high speech checks with low base CHA and Speech.
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