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TopicSide effects on medications don't "stack" right?
LanHikari10
06/09/18 2:35:47 AM
#21:


Depends on what medicines we're talking about. Even if several medicines are metabolized in the liver, that doesn't mean they're going to stack per se. There's a whole class of CYP450 enzymes that metabolize different drugs even in the same class. And even drugs that work similarly or are for the same thing don't have the exact same properties, whether that means different protein binding in the blood, CNS penetration, etc.

Just as an example, I see patients all the time on several different types of antidepressants at the same time, most typically I see an SSRI/SNRI with a TCA.

But at the end of the day, it really depends on the medicines in question, but I'd assume if they were all prescribed by the same doctor and filled by the same pharmacy it'll be okay.
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