LogFAQs > #971983111

Monday Night Football - lol rip
South Park - So most of the main characters are children or regular townsfolk, so I could make a pretty good run here. The problem comes as soon as side characters show up and I'm fighting Jesus or Satan or Santa Claus or Crab People or Mecha-Steisand or ManBearPig
Ed Edd 'n' Eddy - All kids, and I'm 99% sure I could solo anyone here except Ed in a fist fight (cartoon physics being the only thing that makes it iffy). But like hombad showed, Ed is freakishly strong, and given that his name is in the title I imagine he's one of the first ones I'd be fighting.
Frasier - Kind of a boring answer, but yeah, a bunch of old, white collar people. I'd give this to EE&E without Ed, but with Ed I have to go Frasier

I Think You Should Leave - There's nobody here that's like crazy strong, but there are a LOT of characters, each more random and unpredictable than the last. It's a numbers game more than anything. It does have the bonus of most of the characters being very punchable though.
It's Always Sunny in Philadelphia - Is this fat Mac or ripped Mac we're dealing with here? Frank goes down easy, but there are plenty of people here that would straight up kill me without hesitation, and there's gonna be a lot of dirty fighting going on here.
Yu-Gi-Oh! - This is a tricky one. I'm not personally counting things like Blue Eyes White Dragon, who is technically a being in the show that originated the cards, but it's a stretch to call that part of the show's cast. Now some of them have Milennium items, but this is a fist fight so things like weapons wouldn't be used, but I'd also think like Pegasus' Milennium Eye is fair game (not that it'd help him, because there's zero chance Pegasus handles a fist fight). Bandit Keith probably puts up a fight, and maybe like Tristan, but most of these characters are dorky little dweebs. I think I give this a tiny edge over ITYSL but it's super close
Kolchak: The Night Stalker - Never heard of this before, but it seems kinda like Twilight Zone or even Dresden Files where there's just a bunch of terrifying and deadly stuff just thrown at you randomly one after the other