LogFAQs > #968065959

https://therunefactory.fandom.com/wiki/Love_Potion

Closest thing I can find, game-wise.

Anime-wise, I can only think of Familiar of Zero, where it still wasn't treated as a good thing, but its intended purpose was to stop a guy from hitting on other girls besides his established girlfriend, so it sorta qualifies for this topic.

The main heroine drinks it by accident, which makes her honest about her feelings towards the main lead and making her less of a tsun and more of a dere, but they still spend the rest of the episode getting the antidote. She remembers all the embarrassing things she did while under its influence, so things quickly go back to the status quo, but it was one of her cutest moments.