Underleveled posted... Metroid Prime 4 and BotW2 should, at the absolute least, get concrete status updates, even if we get no actual footage.
They'll probably show off upcoming stage(s) for Splatoon 3. I wouldn't even be surprised if a new one is out "later today."
MAYBE a status update on Advance Wars. I could them trying to do this one with as little fanfare as possible, like just throwing it into the ending montage.
Life is Strange Remastered Collection is still TBA 2022 despite being out on everything else since February. Maybe we'll get a date on that.
Maybe they'll show off a new Pokemon or two, and/or bring attention to the Shiny Eternatus event (since Europe currently has a mythical event going on they could counterpart that segment).
They ought to highlight some of the upcoming N64 games for Switch Online.
And I know I always say this but let's see some dead/dormant 1st/2nd party franchise (Golden Sun, Punch-Out, F-Zero, Kid Icarus, etc) show up in some form!
EDIT: Oh yeah, Bayonetta 3 is a must!
where's my update on Phase 2 of the Xenoblade 3 Expansion Pass