Sheena Fujibayashi (Tales of Symphonia)
http://crippledotaku.files.wordpress.com/2009/02/sheenaf.jpg?w=450
Sheeva (Mortal Kombat)
Shelke the Transparent (FFVII: Dirge of Cerberus)
Shernini Schie (Record of Agarest War Zero)
http://www.nautiljon.com/images/jeuxvideo_persos/5/0/9/shernini_schie_905.jpg?0
Sheryl Nome (Macross Frontier)
She-Venom (Marvel Comics)
Shigure Kosaka (Kenichi The Mightiest Disciple)
http://media.animevice.com/uploads/0/697/291178-089973016f6ac0a014a397effa755d38.jpeg
Shikieiki Yamaxanadu (Touhou Project)
Shiki Misaki (The World Ends With You)
Shion Sonozaki (Higurashi no Naku Koro ni)
Shizuku (Omamori Himari)
Sialeeds Falenas (Suikoden V)
Sindel (Mortal Kombat)
--
You know what they say: If you can't beat them, join them. If you can't join them, burn their house to the ground!