Well there was once a time when MvC3 was going around losing to the likes of No Mercy and Crash Team Racing. I think MvC3's case is more or less the same as The Wind Waker's - people love to see it pull off silly upsets, but when it's the favorite to win, its loud hatebase comes back to bite it.
Seriously, everytime I thought The Wind Waker would lose, it won. Well, except against Kingdom Hearts, but Wind Waker would've won that match too if I was there (plus I expected KH to destroy Wind Waker - although given how Wind Waker has beaten the only other big Square game it faced, I think we can take it as an indication that WW is quite strong).
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Currently Playing - StarCraft: Brood War