Trying to rank something like this is an exercise in futility imo, but I expect Female, Mexican, Single, and Married Without Family to have the easiest go of things within our lifetimes. I think a Gay, Atheist, or Muslim candidate will have more of his work cut out for him. As for Asians, are there even any national-level Asian politicians outside of Hawaii?
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Yoblazer: http://i44.tinypic.com/5nw45i.jpg
Watch and you'll see... someday I'll be... part of your world!