-Ada makes an appearance, though not in Tall Oaks.
- Leon's scenario is similar to Revelations in terms of gameplay and atmosphere. Item boxes return.
- Chris' scenario is like RE5 and is the longest of the three. Features locations such as Lanshiang (China, fictional city), Serbia and New York City.
- Jill Valentine is now Jill Redfield. Chris married her shortly after the events of RE5. She's no longer a field agent, but is still at the BSAA as a bioweapons advisor in the New York City HQ.
- Helena Harper hides something relevant to past Resident Evil events.
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