Lurker > BendoHendo

Hoping this story inspires others. Went from 15k -> 128k

2014: Graduated college with BS in math, and went to grad school for math. Dropped out after several weeks because of mental health reasons. Didn't know what I was going to do for work.

2015: Got first job out of college as a math tutor at a math learning center. Made 15k a year. During this time, studied for Society of Actuary exams and passed 2 of them.

2016: Moved across the country vertically for first fulltime job at an insurance/consulting company. I was a glorified call center rep, not really using any math. Salary = 49k. Passed one more society of actuary exam. Developed a unique skill by working on public speaking and presentation skills.

2018: Moved across the country horizontally for second fulltime job at another insurance company. This job made use of my public speaking skills, and was able to do it 25% of the time. Salary = 83k. Stopped passing professional actuarial exams.

2019: Promoted, salary = 112k

2020: Salary increased to 115k, with bonus = 128k.

I'm not especially smart, just hard working and willing to do things that other people think suck/are boring.

Ask me anything.

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Mr_Rian posted...

The use of adjuvants has also been considered for avoiding the potential undesired effects of coronavirus vaccination. Adjuvants are substances that potentiate and modify the immunogenicity and protection efficacy of the vaccines [125]. A group of researchers found that by using a chemical adjuvant (a delta inulin-based polysaccharide), lung immunopathology previously observed in mice after SARS challenge experiments were no longer observed [126]. It was hypothesized that the adjuvant helped to avoid an exacerbated Th2-polarized response after challenge causative of the adverse effects. This is a case where an adjuvant not only enhanced vaccine-induced protection but also helped to minimize adverse effects due to coronavirus vaccination.

Yes, so which vaccine candidates use adjuvants? Do we know?

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monkmith posted...

here @BendoHendo , this pretty well summarizes the current understanding of coronavirus vaccines.

https://link.springer.com/article/10.1007/s40121-020-00300-x#Sec2

search for ADE for your specific question.

Interesting:

The induction of ADE using the S glycoprotein has been tackled by using truncated versions of the same protein. It is believed that the use of the receptor-binding domain (RBD) or the S1 subunit of the S glycoprotein can lead to the induction of neutralizing antibodies while avoiding ADE. The idea is to focus the induction of antibodies to relevant S regions for efficient virus neutralization and, by doing so, to avoid the induction of potential non-neutralizing antibodies targeting other regions of the S protein. Even though there seems to be little direct evidence proving this idea, vaccines based on these regions have already been tested, allowing the induction of high titers of neutralizing antibodies and a certain level of protection in small animals and non-human primates [49, 50, 56, 78].

I guess we will see if using the truncated version of the same protein helps. The paragraph states this has not been proven yet. Hopefully we will know within a couple of years of the vaccine being out. Do we know which vaccines (Moderna, Pfizer, Astrazenica) use the truncated version of the protein?

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ShotgunSilencer posted...

He's not being anti Vax tho. He posted legitimate concerns with links to information to help understand his concerns.
Nowhere did he say vaccines are bad and he's against them.

Exactly. I get my flu shot every year and have taken every vaccine ever as required by public education. I am not anti-vax! I am concerned and cautious about a brand new vaccine that has been studied for only several months.

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Irony posted...

Not reading your post. Get fired

"I hate critical thinking."

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I won't be getting the COVID vaccine, and I feel justified after reading official documentation from the FDA, uk.gov, as well as research papers linked. I have a few questions I'm trying to put my mind at ease about.

I'm concerned that there were no animal studies, and more specifically, the challenge phase of animal studies. Typically, animals receive the vaccine, then it is challenged by receiving the real virus. This is important, because the SAR-COV-1 vaccine failed, and also coronavirus vaccines tested in cats have failed after the the challenge, resulting in deaths of the cats.

See: https://pubmed.ncbi.nlm.nih.gov/2154621/ (paper on the challenges of vaccinating cats with a coronavirus vaccine, resulting in death of the cats)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115537/

Antibody-dependent enhancement (ADE) has been observed in vaccinated and wild-type infections of FIP. ADE is thought to potentiate viral infection through the infection of macrophages. Viral entry into macrophages occurs when antibodies bind the virus and attach to macrophages via the Fc region of the antibody and its interaction with cell surface expressed Fc receptors [46]. Neutralizing antibodies can also be enhancing antibodies if antibody titer is low or is of the IgG class [47], [48]. Because macrophages increase with viral disease, this cell type may provide an abundant reservoir for the virus and thus expansion of the virus in the host. Some similarities between FIP and SARS exist. First, in both cases macrophages can be infected with the virus [9], [49], and in the case of SARS, the etiology of disease is contributed by infiltrating alveolar macrophages leading to pneumonitis [8]. Second, the treatment with corticosteroids and/or interferon alpha ameliorates SARS disease [50], suggesting an inflammatory, immune-mediated disease. While there has been no observation of ADE during SARS infection, it is worth noting that one coronavirus, FIPV, is capable of eliciting ADE and in the evaluation of vaccines, we may want to consider this possible outcome. However, the difficulty in testing animal models for ADE bears the caveat that if ADE is not observed; it has not proved that vaccines are safe with regard to ADE in humans. In contrast, if an animal model for ADE is developed, we may learn more about the mechanism of SARS-induced ADE, which may help form the basis for developing guidelines for safe vaccine development.

I'm concerned about an ADE (Antibody Dependent Enhancement). And also mid to long term effects of the vaccine. Does having the spike proteins from the vaccine put someone at risk for problems down the road for things like cancer? Does this vaccine create issues with fertility?

See the FDA's document for side effects of the they are watching for. On page 16, Vaccine enhanced disease is listed and so is pregnancy issues. There's also a large list of severe illnesses and autoimmune conditions listed.

https://www.fda.gov/media/143557/download?fbclid=IwAR2V6aqOmjD2WZ2uc3VQEUrDDEKDkpHGMAPXkYlb1U9wgZqu7AOp81DsyBE

Note that Transverse myelitis is listed, which is a spinal and neurological condition, which occurred in the Astrazenica/Oxford vaccine

We also know from UK documentation of the vaccine, that there is no data on fertility. Please see this file on page 6:

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/941452/Information_for_healthcare_professionals.pdf?fbclid=IwAR1DdnB-VVphxOKrmXmi0iAOXZOTeNBfydQPA4s4_QmN4gQXID5gKrT5iQE

"Fertility - It is unknown whether COVID-19 mRNA Vaccine BNT162b2 has an impact on fertility"

Don't you think we should know this before taking the vaccine?

Anyways, these are my concerns, looking for some answers. Any thoughts?

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