Its kinda a case by case basis for me.
Like, I played through Spider-Man 2 and still enjoyed playing as Miles despite being a 46 year old playing a Black/Puerto Rican teenager.
But (and I get a ton of shit for it, but whatever) I tend to not find a lot of female comics funny, especially ones that do a lot of relationship/dating humor, because Ive never experienced what its like being a single female in the dating scene.
It takes zero effort to be a good person.