RuneScape comes to mind.

Stakes to kill Vampyres, salt to kill rock slugs, hammers to kill gargoyles etc.

Its annoying if you miss click though.

Dagoth Ur in Morrowind too, gotta slap the heart so he doesnt come back.
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Is sticking your tongue on a 9-volt battery a masculine gesture?-Questionmarktarius

Boss fights that end with a particular requirement.

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