I didn't play Loop Hero but I enjoyed reading Para's post
I did think of Hades though, as while I enjoyed it, I don't think it pass the "50 hours test" either, imo. I enjoyed it a lot for the first 40 or so hours but it became super repetitive and I still had stuff to do but I didn't have fun anymore
It was just not on the same level of Binding of Isaac in which it not only pass the 50 hours test, but the 200 hours test as well because literally every run is so different from the previous and it's not even close