It might be more difficult later on, i don't recall. In any case, you don't want to fight the moon presence and you don't need to explore for weapons or anything, so the critical path really shouldn't be an issue. You have gascoigne, amelia, shadows, rom, the monster from the moon whose name escapes me, micolash, mergo, and gehrman.
Unless of course you want to make it a point to defeat all bosses in ng+ as a personal achievement. In which case... good luck with the orphan.