Despite being right-handed, I usually use a mouse with my left hand. Growing up, my parents had the computer set up that way so they could write with their right hands while using the mouse, so that's what I got I used to and still use to this day (though I'm fine using my right hand). As it turns out, lefty mouse is actually ergonomically superior because it lets you centre the important part of the keyboard (everything left of the arrow keys) in front of the monitor while still having the mouse closer to the centre of your body (and therefore a more neutral position). With the mouse on the right, you either have to reach both hands to the left to use the keyboard if you keep the mouse nearby, or you have to reach quite a bit further for the mouse if you centre the keyboard (assuming you have a standard keyboard and not one that lacks a numpad, allows you to move it, or has it on the left-hand side). It also works well for doing accounting work, because I can click around while entering numbers with the numpad.
I do swap it over to the right for KB+M games, though, at least ones that are WASD-based. Occasionally I'll just use the arrow keys instead (it's how I played WoW for many years), but since playing more PC games I'm generally more comfortable with WASD even if it is a game where rebinding everything to support lefty mouse isn't totally impractical. Unfortunately, this means I'm limited to ambidextrous mice, and there are surprisingly few options for those that have a decent number of extra buttons and are also available in local stores so I can see how they feel before buying them.
captpackrat posted...
I play games with my right hand on the keyboard in the normal typing home row position: pinky on the A, ring finger on the S, middle finger on D, and index finger on F. In this position, moving your ring finger to W is rather awkward when using A or D to strafe, but moving your ring finger down to X to back up works just fine when strafing.
Assuming you mean left hand (using the right hand how you described would only work if you turned the keyboard upside down first), I have my ring, middle, and index fingers on A, W, and D, respectively, hitting S with my middle finger as needed and using my pinky for shift/ctrl. With the layout you described, I can indeed see why hitting W would be infeasibly awkward.