I upgraded at least 20 weapons to +24/+9 and I tried using a variety of things but nothing ever felt as good as Bloodhound's Fang or Blasphemous Blade to me. Rivers of Blood is definitely good but I think I prefer the feel of heavier weapons. I do like to run around the lower level areas with different weapons but when it was time for a tough fight, I break out the Fang
Delicious and vicious, while maliciously nutritious.