Yeah I take Zoloft but a very minor dose. It isn't for depression though it is for anxiety/panic disorder, basically to prevent me from having panic attacks.
Don't notice any effect naturally unless if I think about it and realize how the frequency of my panic attacks and extended periods of worrying have decreased significantly.
My only side effect really is weight gain, I've gained maybe 10 pounds in the past 6 months. Still look pretty slim but I am 6'2" and 215 lbs now. Luckily a good amount of that is my broad frame and muscles though.