Which moment in human history had the most negative impact?

Poll of the Day

Definitely Anita Sarkeesian.

There were up-sides to the Shoah such as fairly immediate advances in medicine, and political philosophies (Human Rights, international cooperation, tolerance). In fact, the benefits may have outweighed the drawbacks, not that I'm suggesting the ends justified the means by any stretch.

What has Anita done other than make people suffer on a similar if not greater scale, and for no benefit at all?
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